Hetarylcyanamides: Synthesis of Novel Thiazole, Triazole and Pyrimidine Derivatives and Prediction of their Biological Activity via PASS Inet | ||||
Journal of Pharmaceutical and Applied Chemistry | ||||
Volume 3, Issue 2, September 2017, Page 1-7 PDF (853.36 K) | ||||
Document Type: Original Article | ||||
DOI: 10.18576/jpac/030310 | ||||
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Authors | ||||
Ahmed Khodairy; Amr H. Moustafa; Walaa W. Ahmed | ||||
Department of Chemistry, Faculty of Science, Sohag University, Sohag 82524, Egypt | ||||
Abstract | ||||
Some new N-thiazolylaminopyrimidine derivatives 3a,b have been synthesized via the reaction of 1-(4,6- dimethylpyrimidin-2-yl)thiourea 2, obtained via sulfidation of cyanamide 1a with phenacyl bromides. Acid hydrolysis of N-(pyrimidin-2-yl)cyanamides 1b,c gave the corresponding pyrimidinylurea derivatives 4a,b. Reaction of cyanamide 1b with thieno[2,3-b]thiophene derivative 5, at molar ratios (1:1 or 2:1), gave the unexpected thienopyrimidine derivative 6, not the expected bis-thienopyrimidine derivative 7. Triazolylaminopyrimidine derivative 8 has been obtained via the heterocyclization reaction of cyanamide 1b with benzhydrazide. Prediction the activity spectra of synthesized compounds using PASS Inet at Pa > 70%, showing high probability of Mucomembranous protector, Transcription factor STAT inhibitor and Gluconate 2-dehydrogenase (acceptor) inhibitor. | ||||
Keywords | ||||
Hetarylcyanamide; Aminothiazole; Thienopyrimidine; Aminotriazole; PASS Inet | ||||
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