Effect of Two Carotenoids (Lycopene and β-Carotene) Supplementation on Hyperlipidemia and Lipid Peroxidation in Experimental Albino Rats | ||||
| Journal of High Institute of Public Health | ||||
| Article 1, Volume 45, Issue 1, April 2015, Page 1-7 PDF (680.8 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jhiph.2015.20262 | ||||
 View on SCiNiTO | ||||
| Author | ||||
Salem Salem 
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| Faculty of Specific Education, Fayoum University, Egypt | ||||
| Abstract | ||||
| Background: Carotenoids have been known to have important beneficial properties for human health and gained importance in recent years. Objectives: The present study aimed to investigate the effect of supplementation with two carotenoids (Lycopene and β-Carotene) separately or in combination, on lipid peroxidation and some endogenous antioxidants in addition to their effect on serum levels of lipoproteins in male rats. Methods: Thirty male Sprague-Dawley Albino rats, were randomly divided into 5 groups, normal control group fed on standard diet, 4 groups were divided to positive control group fed on high fat and cholesterol diet only, and the remaining 3 groups were fed on high fat and cholesterol diets supplemented with single antioxidant Lycopene 350mg/kg diet, β-carotene 350mg/kg diet, or mixture of Lycopene and β-carotene, for 4 weeks. The following parameters were measured, serum total cholesterol (TC), HDL, LDL, serum triglyceride (TG) levels, blood and liver glutathione (GSH), and livers malondialdhyde (MDA). Results: Supplementation of High Fat Diet (HFD) with lycopene (HFD+ LYC), β-Carotene (HFD+ B-car) and their mixture (HFD+ (LYC+ B-car)) produced a significant reduction of Serum TC, LDL and TG levels, and a significant elevation of serum HDL levels. The supplementation of lycopene, β-carotene or their mixture resulted in a significant reduction of liver MDA, and a significant elevation of liver and blood glutathione (GSH), in comparison with the levels of HFD group. Conclusion: These findings suggest that lycopene and ß-carotene supplementation, altered the pro-oxidation and anti-oxidation balance and suppressed oxidative stress by modulating endogenously the antioxidant system and cholesterol metabolism. | ||||
| Keywords | ||||
| Rats- Lycopene - ß-carotene - LDL- HDL- MDA- Blood GSH; Liver GSH | ||||
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