Synthesis and Antimicrobial Activity of Some Furfural Substituted Bisdimedone Derivatives | ||||
Journal of Pharmaceutical and Applied Chemistry | ||||
Volume 2, Issue 2, May 2016, Page 89-93 PDF (189.88 K) | ||||
Document Type: Original Article | ||||
DOI: 10.18576/jpac/020204 | ||||
View on SCiNiTO | ||||
Authors | ||||
Mukhtar A Wani1; Javeed A Farooqi1; Wajahat A Shah2 | ||||
1IGNOU New Delhi, India | ||||
2University of Kashmir, India | ||||
Abstract | ||||
Bisdimedone derivatives were synthesized by the method adopted by Horning and Honing. All the newly synthesized compounds showed antimicrobial activities against certain bacterial and fungal strains. The compounds 2-(2-chloro-phenyl)-5-bis(1,3diketo-5,5-dimethyl cyclohexyl)-methylfuran and 2-(4-flor-phenyl)-5-bis(1,3diketo-5,5-dimethyl cyclohexyl)methylfuran showed good activity against Proteus mirabilis and Klebsiella pneumonia and 2-(4-chloro-phenyl)-5-bis(1,3diketo-5,5-dimethyl cyclohexyl)-methylfuran and 2-(2-chloro-phenyl)-5-bis(1,3diketo-5,5-dimethyl cyclohexyl)-methylfuran showed prominant activity against Staphylococcus aureus. Bisdimedone derivatives shows fungicide activity as well. | ||||
Keywords | ||||
bisdimedone; antimicrobial activity; fungicide xanthenes | ||||
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