The Roles of Apigenin Cream on Wound Healing in Rabbits Model | ||||
| Journal of Applied Veterinary Sciences | ||||
| Article 1, Volume 7, Issue 1, January 2022, Page 1-5 PDF (769.03 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/javs.2021.97151.1104 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Ammar A. Rajab1; Wael T. Al-Wattar2; Ghada A.Taqa  3
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| 1Ministry of Health, Nineveh Health Directorate, Mosul, Iraq. | ||||
| 2Department of Oral and Maxillofacial Surgery, College of Dentistry, University of Mosul , Mosul, Iraq. | ||||
| 3Department of Dental Basic Science, College of Dentistry, University of Mosul, Mosul, Iraq. | ||||
| Abstract | ||||
| Aims: The objective of this study is to evaluate healing effect of topical Apigenin cream 2% in the skin of rabbits .Materials and Methods: 24 healthy Newzealand adult male rabbits approximately same age were involved in this study, , all animals anesthetized using mixture of 40 mg/kg ketamine injection and xylazine 4 mg/kg intramuscularly , The skin of the dorsum area of each rabbit was shaved, then three incisions (1cm in length) were made on the skin with scalpel blade no.15. Wounds were left without suturing to heal by secondary intention healing, and each animal had three wounds ( wounds divided into three groups according to the type of treatment): one treated with Apigenin cream twice a day, the other with cold cream twice a day, and the third wound was left untreated. The application of cream was repeated daily, the wound size and the ratio of wound contraction assessed at first, fourth and seventh days of study. Results : group treated with Apigenin showed significantly better wound healing capacity in the skin of rabbits, wound size and wound contraction ratio was superior in Apigenin group in comparison to control positive and negative groups. Conclusion : Apigenin cream enhance wound healing potential of skin in rabbits . | ||||
| Keywords | ||||
| Apigenin; Wound contraction ratio; Wound healing; Wound size | ||||
| References | ||||
|
AHIRWAR, L.K., KALRA, P., SHARMA, S., MOHAMED, A., MITTAL, R., DAS, S., and BAGGA, B., 2021. Linezolid shows high safety and efficacy in the treatment of Pythium insidiosum keratitis in a rabbit model. Experimental Eye Research, 202, p.108345. https://doi.org/10.1016/j.exer.2020.108345
BYUN, S., PARK, J., LEE, E., LIM, S., YU, J.G., LEE, S.J., CHEN, H., DONG, Z., LEE, K.W., and LEE, H.J., 2013. Src kinase is a direct target of apigenin against UVB-induced skin inflammation . Carcinogenesis, 34(2), pp.397-405.
DUARTE, C.M.E., QUIRINO, M.R.S., PATROCÍNIO, M.C., and ANBINDER, A.L., 2011. Effects of Chamomilla recutita (L.) on oral wound healing in rats. 16:716–721.http://hdl.handle.net/10550/60099
GONZALEZ, A.C.D.O., COSTA, T.F., ANDRADE, Z.D.A., and MEDRADO, A.R.A.P., 2016. Wound healing-A literature review. Anais brasileiros de dermatologia, 91, pp.614-620.
HUANG, J., CHEN, L., GU, Z., and WU, J., 2019. Red jujube-incorporated gelatin methacryloyl (GelMA) hydrogels with anti-oxidation and immunoregulation activity for wound healing. J. Biomed. Nanotechnol, 15, pp.1357-1370.
HUMBERT, P., MEAUNE, S., and GHARBI, T., 2004. Wound healing assessment. Phlebolymphology, 47, pp.312-319.https://www.phlebolymphology.org/wound-healing-assessment/
HUNCKLER, J., and DE MEL, A., 2017. A current affair: electrotherapy in wound healing. Journal of multidisciplinary healthcare, 10, p.179.
IBRAHIM, R.T.I., MAHMMOD, A.A.M., and TAQA, G.A.R.T., 2020. Synthesis of Silver Nanoparticles Using Catechin and Apigenin and Study their Antioxidant Effect on the Laboratory Rats. College Of Basic Education Researches Journal, 16(3), pp.919-943.https://berj.mosuljournals.com/?_action=article&keywords=Synthesis+of+Silver+Nano+particles
KHUNGER, N. 2017. Accelerated wound healing: Harnessing the power of platelets, biomaterials, stem cells and gene therapy. Journal of cutaneous and aesthetic surgery, 10(1),p.1.
LIM, H., and KIM, H.P., 2007. Inhibition of mammalian collagenase, matrix metalloproteinase-1, by naturally occurring flavonoids. Planta Medica, 73(12), pp.1267-1274.https://doi.org/10.1055/s-2007-990220
LIU, J., CHEN, Z., WANG, J., LI, R., LI, T., CHANG, M., YAN, F., and WANG, Y., 2018. Encapsulation of curcumin nanoparticles with MMP9-responsive and thermos-sensitive hydrogel improves diabetic wound healing. ACS applied materials & interfaces, 10(19), pp.16315-16326.https://doi.org/10.1021/acsami.8b03868
LOPEZ‐JORNET, P., CAMACHO‐ALONSO, F., GÓMEZ‐GARCIA, F., MOLINA MINANO, F., CAÑAS, X., SERAFÍN, A., CASTILLO, J., and VICENTE‐ORTEGA, V., 2014. Effects of potassium apigenin and verbena extract on the wound healing process of SKH‐1 mouse skin. International wound Journal, 11(5), pp.489-495.
MAN, M.Q., HUPE, M., SUN, R., MAN, G., MAURO, T.M., and ELIAS, P.M., 2012. Topical apigenin alleviates cutaneous inflammation in murine models. Evidence-Based Complementary and Alternative Medicine
MARTIN, P., and NUNAN, R., 2015. Cellular and molecular mechanisms of repair in acute and chronic wound healing. British Journal of Dermatology, 173(2), pp.370-378. https://doi.org/10.1111/bjd.13954
MOTEALLEH, B., ZAHEDI, P., REZAEIAN, I., MOGHIMI, M., ABDOLGHAFFARI, A.H., and ZARANDI, M.A., 2014. Morphology, drug release, antibacterial, cell proliferation, and histology studies of chamomile‐loaded wound dressing mats based on electrospun nanofibrous poly (ɛ‐caprolactone)/ polystyrene blends. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 102(5), pp.977-987. https://doi.org/10.1002/jbm.b.33078
NAGAR, H.K., SRIVASTAVA, A.K., SRIVASTAVA, R., KURMI, M.L., CHANDEL, H.S., and RANAWAT, M.S., 2016. Pharmacological investigation of the wound healing activity of Cestrum nocturnum (L.) ointment in Wistar albino rats. Journal of Pharmaceutics, 1-8. https://doi.org/10.1155/2016/9249040
REHECHO, S., HIDALGO, O., DE CIRANO, M.G.I., NAVARRO, I., ASTIASARÁN, I., ANSORENA, D., CAVERO, R.Y., and CALVO, M.I., 2011. Chemical composition, mineral content and antioxidant activity of Verbena officinalis L. LWT-Food Science and Technology, 44(4), pp.875-882.
SHANKAR, M., RAMESH, B., KUMAR, D.R., and NIRANJAN, B.M., 2014. Wound healing and its importance-a review. Der Pharmacologia Sinica, 1(1), pp.24-30.https://www.researchgate.net/publication/318877193 | ||||
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