Methotrexate and Misoprostol against Misoprostol Alone for Early Medical Abortion: Comparative Study | ||||
| Journal of High Institute of Public Health | ||||
| Article 4, Volume 44, Issue 1, April 2014, Page 21-24 PDF (476.75 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jhiph.2014.20338 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Engy Taher  ; Manal Swelam; Amr Mansy; Marwa Elgammal
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| Obstetric and Gynecology Department. Faculty of medicine, Alexandria University. Egypt | ||||
| Abstract | ||||
| Background: Vaginal mifepristone oral misoprostol have proven to be highly effective medical abortion methods and are used widely in in modern countries. Objectives: The objective of this study is to compare the efficacy for two medical abortion regimens used in one clinic setting misoprostol alone, intramuscular methotrexate and vaginal misoprostol. Methods: An intervention study was conducted on a total of 100 randomly selected women with gestations of first-trimester pregnancy, who sought a missed abortion. Study population was assigned as two groups, the first was subjected to vaginal administration of Misoprostol and the second was subjected to IM injection of methotrexate and self-administration of vaginal misoprostol After 72h. All patients were followed up for recording any side effects of the drugs, progress of abortion & if there was any need for surgical interference [manual vacuum aspiration (MVA) or dilatation and curettage Results: Success rate of the methotrexate regimen was 80% and did not differ significantly from the misoprostol regimen that had success rate of 84%. Conclusions: In this real-use setting, the use of misoprostol in combination with methotrexate or alone for the missed abortion termination are both safe and effective methods without serious side effects. | ||||
| Keywords | ||||
| Methotrexate; misoprostol; Pregnancy; Abortion | ||||
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