CLAUDIN-3 Protein Expression Relation with Dermatological Diseases: Review Article | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 38, Volume 85, Issue 2, October 2021, Page 3687-3690 PDF (807.27 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2021.203739 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Shorouk Hegazy Abdel Hamid; Ayman ElSayed; Hagar Awad | ||||
| Abstract | ||||
| Background: When it comes to barrier and pore creation in metazoans, especially vertebrates and tunicates. Claudins are an important family of transmembrane proteins. In epithelia and endothelia's apical junctional complex, chordate claudins are crucial architectural proteins for tight junction strands. Psoriasis patients often have some degree of subclinical intestinal irritation. In gastrointestinal mucosal biopsies, lymphocytic infiltration is found in about 60% of patients. Intestinal absorption is hampered by structural and functional changes in the colon caused by inflammatory cells. Those who have psoriasis have abnormalities in fecal fat excretion, decreased D-xylose absorption, and impaired lactase activity.Objective: To assess the relation between CLAUDIN-3 protein with dermatological diseases. Conclusion: Claudin-3 is a key component of tight junctions, which may serve as marker of gut barrier integrity. Claudin-3 level may be altered in patients with psoriasis. | ||||
| Keywords | ||||
| CLAUDIN-3 protein; Psoriasis | ||||
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