A retrospective study on pregabalin toxic cases referred to poison control Center | ||||
| Mansoura Journal of Forensic Medicine and Clinical Toxicology | ||||
| Article 11, Volume 30, Issue 1, January 2022, Page 59-69 PDF (541.38 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjfmct.2021.89427.1038 | ||||
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| Authors | ||||
Mena Shenouda  1; Rania Radwan2; Mona Moussa3; Maha Hilal4
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| 1Forensic Medicine and Clinical Toxicology Department, Sohag University, Sohag | ||||
| 2Forensic Medicine & Clinical Toxicology Faculty of Medicine -Sohag University, Sohag, Egypt. | ||||
| 3Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Ain Shams University, Cairo, Egypt | ||||
| 4Department of Forensic Medicine & Clinical Toxicology, Faculty of Medicine, Sohag University, Egypt | ||||
| Abstract | ||||
| Pregabalin is a psycho-active medicinal drug that exhibits analgesic, anticonvulsant, anxiolytic and antidepressant effects. In the United States, pregabalin is approved for the treatment of neuropathic pain associated with diabetic neuropathy, post herpetic neuralgia, epilepsy (partial onset seizures) and fibromyalgia. The aim of study was studying the relation between pregabalin toxicity and sociodemographic data (Age - sex- occupation), outcome, risk factors of pregabalin toxicity and relation between pregabalin abuse and abuse of other drugs. Our retrospective descriptive study was conducted on 70 patients referred to Ain-Shams university hospital due to acute toxicity with pregabalin and admitted to intermediate or intensive care unit (ICU). There was very high statistically significant relationship between mode of intoxication regarding to sex, occupation, and co-ingestion. There was no statistically significant relationship between dose group regarding to duration of stay, coma degree, CNS manifestations and Arterial blood gas ABG. There was statistically significant relationship between co-ingestion and non-co-ingestion regarding to admission, duration of stay, coma grade, CNS manifestation and ABG. The present study revealed that 23 cases were positive tramadol , 5 cases were positive cannabis , 2 cases were positive BZDs and 2 cases were positive opioid. All 70 cases were complete recovery, no complications and no cases died. Pregabalin is nearly safe when used in therapeutic dose and its toxicity appear when it was taken with another drugs of abuse. | ||||
| Keywords | ||||
| Pregabalin; Neuropathic Pain; Intensive Care Unit; Intoxication | ||||
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