Ulcerative Colitis, Immune System and Iron Status Inter-Relationship and the Protective Role of Date and Grape Seed Extracts in Rat Model
Al-Okbi, S., Al-Siedy, E., Mohamed, R., Mabrok, H., Mehaya, F. (2022). Ulcerative Colitis, Immune System and Iron Status Inter-Relationship and the Protective Role of Date and Grape Seed Extracts in Rat Model. EKB Journal Management System, 65(10), 57-69. doi: 10.21608/ejchem.2021.101187.4702
Sahar Y. Al-Okbi; Enas S.K. Al-Siedy; Rasha S. Mohamed; Hoda B. Mabrok; Fathy M. Mehaya. "Ulcerative Colitis, Immune System and Iron Status Inter-Relationship and the Protective Role of Date and Grape Seed Extracts in Rat Model". EKB Journal Management System, 65, 10, 2022, 57-69. doi: 10.21608/ejchem.2021.101187.4702
Al-Okbi, S., Al-Siedy, E., Mohamed, R., Mabrok, H., Mehaya, F. (2022). 'Ulcerative Colitis, Immune System and Iron Status Inter-Relationship and the Protective Role of Date and Grape Seed Extracts in Rat Model', EKB Journal Management System, 65(10), pp. 57-69. doi: 10.21608/ejchem.2021.101187.4702
Al-Okbi, S., Al-Siedy, E., Mohamed, R., Mabrok, H., Mehaya, F. Ulcerative Colitis, Immune System and Iron Status Inter-Relationship and the Protective Role of Date and Grape Seed Extracts in Rat Model. EKB Journal Management System, 2022; 65(10): 57-69. doi: 10.21608/ejchem.2021.101187.4702

Ulcerative Colitis, Immune System and Iron Status Inter-Relationship and the Protective Role of Date and Grape Seed Extracts in Rat Model

Egyptian Journal of Chemistry
Article 6, Volume 65, Issue 10, October 2022, Page 57-69  XML PDF (530.73 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2021.101187.4702
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Authors
Sahar Y. Al-Okbiorcid 1; Enas S.K. Al-Siedy1; Rasha S. Mohamedorcid 1; Hoda B. Mabrokorcid 1; Fathy M. Mehayaorcid 2
1Nutrition and Food Sciences Department, National Research Centre, Cairo, Egypt
2Food Technology Department, National Research Centre, Cairo, Egypt.
Abstract
Ulcerative colitis (UC) is an inflammatory bowel disease with un-elucidated pathogenesis. Thorough investigation of immune system and iron status is decisive in UCdevelopment. Safe nutraceuticals for prevention of UC are crucial due to unwanted side effects of UC remedies. The research aimed at studying the changes in immunity and iron status in UC and the protective role of date palm (DP) and grape (G) seed extracts as nutraceuticals.DP and G seed extracts were tested in rats with induced UC. Biochemical and molecular nutrition analysis were applied on blood and colon along with colon histopathology and disease index. Phenolic compounds were analyzed in the ethanol extracts. Results showed that the major phenolic compounds in date and grape seeds were chlorogenic and catechin; respectively. Iron deficiency anemia with elevated colon oxidative stress and inflammatory biomarkers related to immune system were noticed in UC control compared to normal. Both treatments showed variable improvements in the aforementioned changes. Disease index demonstrated date seed extracts to be more efficient than grape. UC histopathological alterations were slightly improved on both treatments.In conclusion; iron deficiency anemia might be interrelated to elevated cytokines and oxidative stress in UC. Both treatments showed variable improvements in UC.
Keywords
Ulcerative colitis immunity iron status; inflammation; oxidative stress; nuclear factor kappa light chain enhancer of activated B cells gene expression, expression of inducible nitric oxide synthase; expression of cyclooxygenase-2; expression of interleukin-1β
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