Hazard Effects of Chronic consumption of Sucralose and Saccharin-Sodium Cyclamate Mixture in Murine Model
El-Hadad, G., Farid, A., El amir, A., Madbouly, N. (2022). Hazard Effects of Chronic consumption of Sucralose and Saccharin-Sodium Cyclamate Mixture in Murine Model. EKB Journal Management System, 65(5), 279-289. doi: 10.21608/ejchem.2021.99319.4622
Gehad El-Hadad; Alyaa Ahmed Farid; Azza Mohamed El amir; Neveen Adel Madbouly. "Hazard Effects of Chronic consumption of Sucralose and Saccharin-Sodium Cyclamate Mixture in Murine Model". EKB Journal Management System, 65, 5, 2022, 279-289. doi: 10.21608/ejchem.2021.99319.4622
El-Hadad, G., Farid, A., El amir, A., Madbouly, N. (2022). 'Hazard Effects of Chronic consumption of Sucralose and Saccharin-Sodium Cyclamate Mixture in Murine Model', EKB Journal Management System, 65(5), pp. 279-289. doi: 10.21608/ejchem.2021.99319.4622
El-Hadad, G., Farid, A., El amir, A., Madbouly, N. Hazard Effects of Chronic consumption of Sucralose and Saccharin-Sodium Cyclamate Mixture in Murine Model. EKB Journal Management System, 2022; 65(5): 279-289. doi: 10.21608/ejchem.2021.99319.4622

Hazard Effects of Chronic consumption of Sucralose and Saccharin-Sodium Cyclamate Mixture in Murine Model

Egyptian Journal of Chemistry
Article 27, Volume 65, Issue 5, May 2022, Page 279-289  XML PDF (1.23 MB)
Document Type: Original Article
DOI: 10.21608/ejchem.2021.99319.4622
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Authors
Gehad El-Hadad1; Alyaa Ahmed Farid2; Azza Mohamed El amir3; Neveen Adel Madbouly email orcid 4
1Zoology department, Faculty of Science, Cairo University, Cairo, Egypt
2professor of immunology, Faculty of science, Cairo university
3Cairo university, Faculty of Science, zoology department
4Zoology department, Faculty of Science, Cairo University, Giza, Egypt
Abstract
Sucralose and saccharin-cyclamate mixture are considered as safe commercial artificial sweeteners with many health authorities instead of natural sugar. We aimed to reveal their effects on the physiological, immunological and histological profiles. Mice were given sucralose (0.3 mg/ml) or saccharin-cyclamate mixture (20 mg/ml) in drinking water for 8 and 16 weeks. Only sucralose caused a temporary significant increase in blood glucose after 8 weeks that was eliminated after 16 weeks. WBCs count was decreased significantly after 16 weeks of sucralose administration. Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), blood urea nitrogen (BUN) and creatinine (Cr) recorded an increase at 8 and 16 weeks due to the two artificial sweeteners intake. Both artificial sweeteners induced a significant increase in interleukin (IL-) 6, tumor necrosis factor-alpha (TNF-α) and circulating lipopolysaccharides (LPS) levels with a progress from 8th to 16th weeks post administration. Both sugars, especially sucralose, caused a severe damage in kidney, liver, pancreas and urinary bladder. Data indicated the adverse effect of Sucralose and saccharin-cyclamate mixture, their consumption can cause a severe inflammation in liver, kidney, pancreas and urinary bladder. Moreover, they may interrupt the intestinal barriers leading to an increase in circulating LPS and pro-inflammatory cytokine secretions.
Keywords
saccharin sodium-cyclamate; sucralose; TNF-α; IL-6
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