Evaluation of stool and urine parameters correlation to CRP and D-dimer in COVID-19 infected adults and their contact children | ||
| Microbes and Infectious Diseases | ||
| Article 5, Volume 3, Issue 1, February 2022, Pages 36-47 PDF (517.9 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mid.2021.102294.1204 | ||
| Authors | ||
| Fetouh Hassanin* 1; Azza Abbas2; Elshahat Alaa2; Mona Schaalan3; Mohamed Rabea4 | ||
| 1Clinical Pharmacy department (pediatrics), Misr International University, Cairo, Egypt | ||
| 2Medical Parasitology, Immunology and Microbiology Department, National Hepatology and Tropical Medicine Research Institute (NHTMI), Cairo, Egypt | ||
| 3Clinical Pharmacy department (pharmacy), Misr International University, Cairo, Egypt | ||
| 4Department of Pediatric Gastroenterology, National Hepatology and Tropical Medicine Research Institute (NHTMI), Cairo, Egypt | ||
| Abstract | ||
| Aim: Aim is to depict suggestive urine and stool parameters in asymptomatic suspected contact children living with COVID-19 infected adults. These parameters will facilitate identifying children who deserve the confirmatory diagnosis of COVID-19 by PCR test. Methods: Study was conducted in the National Hepatology and Tropical Medicine Research institute (NHTMRI) Cairo, Egypt. It included 66 mild COVID-19 adult patients (group1) and their 82 asymptomatic contact children (group 2). Results: In group 1, both C reactive protein (CRP) and D-dimer levels were significantly high. C reactive protein was significantly positively correlated with urinary microalbumin> 30, albumin/ creatinine ratio and urine pus >10 cells / HPF and significantly negatively correlated with vitamin C. D-dimer was significantly negatively correlated with vitamin C. In group 2, CRP and D-dimer were significantly negatively correlated with urine specific gravity (SG), urinary vitamin C. CRP was significantly negatively correlated with stool pus > 10 cells/ HPF, while D-dimer was significantly positively correlated with stool occult blood. Receiver Operating Curve (ROC) analysis revealed that urine SG showed the highest area under the curve (AUC); 0.859, 0.96, sensitivity of 100%, 100% and specificity of 71.8%, 77.8% with reference to D-dimer and CRP; respectively. Conclusions: In contact children of adult COVID-19 proved infection, urine SG, stool occult blood and stool pus > 10 cells/ HPF can be feasible tool for suspected COVID-19 infection, based on its results COVID-19 PCR request can be an imperative option to confirm the diagnosis; particularly in developing countries where detection of COVID -19 by PCR is not readily feasible. | ||
| Keywords | ||
| COVID19; urine; stool; children | ||
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