Correlation between Gene Polymorphisms of Prostaglandin D Correlation between Gene Polymorphisms of Prostaglandin D | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 66, Volume 85, Issue 2, October 2021, Page 3851-3856 PDF (942.89 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2021.205083 | ||||
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| Authors | ||||
Hayam Zakaria Abd Allah  ; Hassan El Banna Khidr; Khalid Mohamed Salah; Nermin Abd El Fattah Raafat
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| Abstract | ||||
| Background: Patients, their families and the community suffer a heavy burden when it comes to asthma because it is both common and possibly life-threatening. It has been postulated that arachidonic acid's most prevalent cyclooxygenase metabolite, prostaglandin D2 (PGD2), is a mast cell activation marker in asthma. Objective: To evaluate association between PGDR-441 polymorphism with risk factors, laboratory characteristics, and severity of asthma in children. Methods: In this cross-sectional study, Forty Egyptian children were genotyped using allele specific polymerase chain reaction (AS-PCR) to assess single nucleotide polymorphism of PTGDR2 receptors. Selected cases were classified according to GINA guidelines and spirometrically assessed to evaluate pulmonary functions. Results: There is significant difference between mild, moderate and severe asthma regarding total IgE level(P1<0.001). 68.0% of the studied patients had Homogenous PGDR2(TT) and 32% had Heterozygous PGDR2(TC). There were no statistically significant associations between PGDR2 Polymorphisms and both of asthma risk factors and laboratory characteristics. There was a statistically significant difference between PGDR2 Polymorphisms and bronchial asthma severity of the studied patients. Heterozygous PGDR2 was associated with more severe bronchial asthma. Conclusion: Our study showed a strong relationship between polymorphism of PTGDR2 receptor and severity of bronchial asthma. | ||||
| Keywords | ||||
| Bronchial asthma; Prostaglandin D Receptor; gene polymorphism | ||||
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