Role of Cytokines as Markers for Immunomodulation in Patients with Hepatitis C | ||||
| Journal of High Institute of Public Health | ||||
| Article 12, Volume 32, Issue 4, October 2002, Page 833-846 | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jhiph.2002.205119 | ||||
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| Authors | ||||
| Mona H. El-Sayed1; Ola Abdel Kader2 | ||||
| 1Department of Immunology, Medical Research Institute, Alexandria University, Egypt | ||||
| 2Microbiology Department, Medical Research Institute, Alexandria University, Egypt | ||||
| Abstract | ||||
| In hepatitis C virus [HCV] infection, mechanisms responsible for liver cell damage are still poorly understood. Various attempts have been carried out to improve the characterization and understanding of the disease. T lymphocytes and immunoregulatory cytokines play an important role in the host response to HCV infection. In the present study soluble interleukin-2 receptor [sIL-2R] and tumor necrosis factor-alpha [TNF-a] were measured in serum by [ELISA], and alpha fetoprotein was assessed by [RIA] in twenty patients with HCV infection. In addition, ten apparently healthy subjects served as controls. The results showed increased serum level of slL-2R in patients group [783.65] U/ml than in control subject [774.19] U/ml. In the same time, the mean level of TNF-a also was significantly elevated in patients [1.51±1.01] than in control [0.39±0.07] ng/ml. Furthermore, three out of twenty HCV +ve patients had elevated serum AFP. These data indicate that the cellular immunity is obviously changed in HCV patients which is noticed by the elevation of sIL-2R and TNF-a, moreover the presence of high level of AFP in some individuals, which might reflect early detection of complications such as liver cirrhosis and hepatocellular carcinoma. | ||||
| Keywords | ||||
| Cytokines; Immunomodulation; Hepatitis C | ||||
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