EFFECT OF OLANZAPINE ON A MODEL OF SCHIZOPHRENIA INDUCED BY ISOLATION REARING IN MALE SPRAGUE DAWLEY RATS
Salah, E., Bahr, M., Medhet, M., Mehrez, S., El-Bakly, W. (2018). EFFECT OF OLANZAPINE ON A MODEL OF SCHIZOPHRENIA INDUCED BY ISOLATION REARING IN MALE SPRAGUE DAWLEY RATS. EKB Journal Management System, 55(1), 113-120. doi: 10.21608/jns.2018.205246
Eman Salah; Mohamed Bahr; Marwa Medhet; Shereen Mehrez; Wesam El-Bakly. "EFFECT OF OLANZAPINE ON A MODEL OF SCHIZOPHRENIA INDUCED BY ISOLATION REARING IN MALE SPRAGUE DAWLEY RATS". EKB Journal Management System, 55, 1, 2018, 113-120. doi: 10.21608/jns.2018.205246
Salah, E., Bahr, M., Medhet, M., Mehrez, S., El-Bakly, W. (2018). 'EFFECT OF OLANZAPINE ON A MODEL OF SCHIZOPHRENIA INDUCED BY ISOLATION REARING IN MALE SPRAGUE DAWLEY RATS', EKB Journal Management System, 55(1), pp. 113-120. doi: 10.21608/jns.2018.205246
Salah, E., Bahr, M., Medhet, M., Mehrez, S., El-Bakly, W. EFFECT OF OLANZAPINE ON A MODEL OF SCHIZOPHRENIA INDUCED BY ISOLATION REARING IN MALE SPRAGUE DAWLEY RATS. EKB Journal Management System, 2018; 55(1): 113-120. doi: 10.21608/jns.2018.205246

EFFECT OF OLANZAPINE ON A MODEL OF SCHIZOPHRENIA INDUCED BY ISOLATION REARING IN MALE SPRAGUE DAWLEY RATS

المجلة الاجتماعية القومية
Volume 55, Issue 1, January 2018, Page 113-120  XML PDF (232.54 K)
Document Type: المقالة الأصلية
DOI: 10.21608/jns.2018.205246
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Authors
Eman Salah1; Mohamed Bahr2; Marwa Medhet3; Shereen Mehrez4; Wesam El-Bakly5
1Teaching Assistant, Department of Pharmacology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
2Professor of pharmacology, Department of Pharmacology, Faculty of Medicine, AinShams University, Cairo, Egypt
3Lecturer of pharmacology The National Center for Social and Criminological Research, Cairo, Egypt.
4Lecturer of Clinical Pharmacology, Department of Clinical Pharmacology Faculty of Medicine, Ain Shams University, Cairo, Egypt.
5Assistant professor of pharmacology, Department of Pharmacology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Abstract
Schizophrenia is a common clinical disorder of psychopathology. Olanzapine has proven efficacy to treat positive symptoms of schizophrenia with enhanced tolerability compared to older first generation antipsychotics. The present study was undertaken to explore the possible effects of olanzapine (6 mg/kg/day) on sociality and cognition in isolated reared rats as a model of schizophrenia. Results: It could be seen that sociality (SI)is deteriorated significantly in isolated reared rats which is very suggestive of induction of schizophrenia's negative symptoms and significantly improved by chronic administration of olanzapine to the extent of social reared (SR) group. Chronic administration of olanzapine obviously decreased cognition indicated by decreased (SPI), increased latency to reach target quadrant and decreased % of time spent in target quadrant day Conclusion: olanzapine had a beneficial effect on increasing sociality in isolated reared rats, but it deteriorates spatial memory and novel object recognition.
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