Dynamin-2 and Angiopoietin-like protein 2 as novel prognostic markers in papillary thyroid carcinoma
hafez, A., abdelbary, A., Elsebai, E., Abdelhai, S., Ibrahim, H. (2022). Dynamin-2 and Angiopoietin-like protein 2 as novel prognostic markers in papillary thyroid carcinoma. EKB Journal Management System, 28(1), 92-105. doi: 10.21608/zumj.2021.97598.2357
abeer M hafez; abeer M abdelbary; Eman Ali Elsebai; Shaimaa Farouk Abdelhai; Hanaa M. Ibrahim. "Dynamin-2 and Angiopoietin-like protein 2 as novel prognostic markers in papillary thyroid carcinoma". EKB Journal Management System, 28, 1, 2022, 92-105. doi: 10.21608/zumj.2021.97598.2357
hafez, A., abdelbary, A., Elsebai, E., Abdelhai, S., Ibrahim, H. (2022). 'Dynamin-2 and Angiopoietin-like protein 2 as novel prognostic markers in papillary thyroid carcinoma', EKB Journal Management System, 28(1), pp. 92-105. doi: 10.21608/zumj.2021.97598.2357
hafez, A., abdelbary, A., Elsebai, E., Abdelhai, S., Ibrahim, H. Dynamin-2 and Angiopoietin-like protein 2 as novel prognostic markers in papillary thyroid carcinoma. EKB Journal Management System, 2022; 28(1): 92-105. doi: 10.21608/zumj.2021.97598.2357

Dynamin-2 and Angiopoietin-like protein 2 as novel prognostic markers in papillary thyroid carcinoma

Zagazig University Medical Journal
Article 11, Volume 28, Issue 1, January 2022, Page 92-105  XML PDF (1.45 MB)
Document Type: Original Article
DOI: 10.21608/zumj.2021.97598.2357
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Authors
abeer M hafez email 1; abeer M abdelbary2; Eman Ali Elsebaiorcid 3; Shaimaa Farouk Abdelhaiorcid 4; Hanaa M. Ibrahim5
1pathology department, faculty of medicine ,zagazig university, Egypt
2assistant professor of pathology
3Clinical oncology department
4Lecturer of Nuclear Medicine, faculty of medicine ,zagazig university, zagazig, Egypt
5pathology department
Abstract
Background: Papillary thyroid carcinoma (PTC) is the most common histological type of thyroid cancer. Fortunately, most PTC patients have favorable outcomes, but about 20% of patients,however, have distant metastases. Therefore, the exploration of new biomarkers to know new characteristics of PTC should be updated.
The aim of our study is to evaluate the possible role of Dynamin-2 and Angiopoietin-like protein 2 (Anglp2) as novel prognostic markers for papillary thyroid carcinoma.
Material and Methods: In our study, we investigated the expression of DNM2 and Anglp2 in 60 cases of PTC . The clinical significance of the markers was evaluated by assessing correlation with the clinicopathological parameters.
Results: High expression levels of both DNM2 and Anglp2 in PTC were significantly associated with advanced tumor stage, lymph node metastasis, bilaterality, multifocal lesion, extrathyroid involvements , recurrence and death.
Conclusions: DNM2 and Anglp2 were independent PTC markers indicating more likely recurrence and poor prognosis. Expression may help to select the high-risk patients for adjuvant targeted therapy.
Keywords
Papillary-thyroid-carcinoma; DNM2; Anglp2; Immunohistochemistry; Prognosis
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