EVALUATION OF IN VIVO ANTIPYRETIC, HEPATOPROTECTIVE AND MOLECULAR DOCKING STUDIES OF Rhynchosia cana (Wild.)DC | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 7, Volume 44, Issue 2, December 2021, Page 349-365 PDF (1.77 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.2021.207154 | ||||
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| Authors | ||||
Praveena Yempada  ; Arya Lakshmi Marrisetti; Ganga Rao Battu
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| Pharmacognosy and Phytochemistry Research Division, University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, Andhra Pradesh, India | ||||
| Abstract | ||||
| To assess the antipyretic and hepatoprotective effects of Rhynchosia cana (Wild.) DC (R. cana) methanol extract in In-silico trials and laboratory animal models. R. cana methanol extract (MERC) was evaluated for antipyretic activity in yeast-induced Pyrexia. R. cana's hepatoprotective ability was evaluated for hepatotoxicity-induced paracetamol albino rats. The GC-MS eluted compound on the protein TGF-β, and PPARα was conducted in silico docking experiments. At doses of 200 and 400 mg/kg, p.o, a single administration of MERC demonstrated strong antipyretic efficacy in albino rats. When the MERC (400 mg/kg) was given preventively for seven days, highly significant hepatoprotective behaviour was also observed. The docking findings of the TGF-β ligand molecule show that the binding affinity of vitexin is - 10.3 Kcal/mol, and Silymarin is -10.6 Kcal/mol. Vitexin displayed a binding affinity of -8.8 Kcal/mol for the PPAR alpha protein, and Silymarin showed an affinity of - 8.2 kcal/mol. The present research indicates that MERC has substantial antipyretic and hepatoprotective effects, as confirmed in the In Silico and In Vivo tests. | ||||
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