COMPARISON OF THE EFFECT OF VITEX AGNUS AND SALVIA OFFICINALIS EXTRACT AT CALCIUM, PHOSPHORUS AND VITAMIN D LEVELS IN POSTMENOPAUSAL WOMEN REFERRING TO BONE MINERAL DENSITOMETRY CENTER: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL
Zeidabadi, A., Emamghoreishi, M., Hosein Dabbaghmanesh, M., Dejbakhat, M., Reza Sasani, M., Akbarzadeh, M. (2021). COMPARISON OF THE EFFECT OF VITEX AGNUS AND SALVIA OFFICINALIS EXTRACT AT CALCIUM, PHOSPHORUS AND VITAMIN D LEVELS IN POSTMENOPAUSAL WOMEN REFERRING TO BONE MINERAL DENSITOMETRY CENTER: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL. EKB Journal Management System, 44(2), 367-376. doi: 10.21608/bfsa.2021.207155
Afsaneh Zeidabadi; Masoumeh Emamghoreishi; Mohammad Hosein Dabbaghmanesh; Majid Dejbakhat; Mohammad Reza Sasani; Marzieh Akbarzadeh. "COMPARISON OF THE EFFECT OF VITEX AGNUS AND SALVIA OFFICINALIS EXTRACT AT CALCIUM, PHOSPHORUS AND VITAMIN D LEVELS IN POSTMENOPAUSAL WOMEN REFERRING TO BONE MINERAL DENSITOMETRY CENTER: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL". EKB Journal Management System, 44, 2, 2021, 367-376. doi: 10.21608/bfsa.2021.207155
Zeidabadi, A., Emamghoreishi, M., Hosein Dabbaghmanesh, M., Dejbakhat, M., Reza Sasani, M., Akbarzadeh, M. (2021). 'COMPARISON OF THE EFFECT OF VITEX AGNUS AND SALVIA OFFICINALIS EXTRACT AT CALCIUM, PHOSPHORUS AND VITAMIN D LEVELS IN POSTMENOPAUSAL WOMEN REFERRING TO BONE MINERAL DENSITOMETRY CENTER: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL', EKB Journal Management System, 44(2), pp. 367-376. doi: 10.21608/bfsa.2021.207155
Zeidabadi, A., Emamghoreishi, M., Hosein Dabbaghmanesh, M., Dejbakhat, M., Reza Sasani, M., Akbarzadeh, M. COMPARISON OF THE EFFECT OF VITEX AGNUS AND SALVIA OFFICINALIS EXTRACT AT CALCIUM, PHOSPHORUS AND VITAMIN D LEVELS IN POSTMENOPAUSAL WOMEN REFERRING TO BONE MINERAL DENSITOMETRY CENTER: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL. EKB Journal Management System, 2021; 44(2): 367-376. doi: 10.21608/bfsa.2021.207155

COMPARISON OF THE EFFECT OF VITEX AGNUS AND SALVIA OFFICINALIS EXTRACT AT CALCIUM, PHOSPHORUS AND VITAMIN D LEVELS IN POSTMENOPAUSAL WOMEN REFERRING TO BONE MINERAL DENSITOMETRY CENTER: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL

Bulletin of Pharmaceutical Sciences Assiut University
Article 8, Volume 44, Issue 2, December 2021, Page 367-376  XML PDF (761.62 K)
Document Type: Original Article
DOI: 10.21608/bfsa.2021.207155
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Authors
Afsaneh Zeidabadi1; Masoumeh Emamghoreishi2; Mohammad Hosein Dabbaghmanesh3; Majid Dejbakhat4; Mohammad Reza Sasani5; Marzieh Akbarzadeh email 6
1M.Sc. of Midwifery, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran
2Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
3Professor of Endocrinology, Department of Internal Medicine, Endocrine and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
4Department of Radiology, Medical Imaging Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
5Department of Nursing, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran
6Maternal-fetal Medicine Research Center, Department of Midwifery, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran
Abstract
Osteoporosis is an important problem in women's health, one of the consequences of
which is bone fracture. This clinical trial was performed in 2015 on 99 (33 patients per group)
postmenopausal women referred to the bone mineral densitometry center. The first group
received one Agnugol tablet (contains 3.2-4.8 mg dry extract of Vitex agnus castus, the second
group received three Salvigol tablets (each contains 100 mg Salvia officinal is dry extract daily
and the third group three placebo tablets per day for 3 months. Calcium, phosphorus and
vitamin D levels were compared before and after the intervention. Results of paired t-test
showed that the mean of calcium and phosphorus level increased after intervention in the Vitex
agnus and salvia officinalis extract groups, but there was no significant difference in the control
group. LSD follow-up test was used, showing that the mean difference of calcium and
phosphorus score between the Vitex agnus, S. officinalis extract and control groups was
significant in pairwise comparisons. However, the difference between the score of phosphorus
level in Vitex agnus and S. officinalis extract groups was not significant after the intervention.
After intervention, the mean of vitamin D increased by 2.4 units in the Vitex agnus group
compared to before the intervention. However, there was no statistically significant difference
between the Vitex agnus and control groups after the intervention compared to before it. The
Vitex agnus was effective in increasing calcium, phosphorus and vitamin D level, while S.
officinalis extract was effective in increasing the level of calcium and phosphorus.
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