EFFECT OF DIFFERENT DOSES OF METFORMIN TABLETS ON METABOLIC SYNDROME COMPONENETS IN WOMEN WITH TYPE 2 DIABETES MELLITUS IN GORGAN (SOUTH EAST OF CASPIAN SEA) | ||||
Bulletin of Pharmaceutical Sciences Assiut University | ||||
Article 15, Volume 44, Issue 2, December 2021, Page 443-453 PDF (621.13 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/bfsa.2021.207167 | ||||
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Authors | ||||
Mona Mirzaali1; Jale Yuzugulen1; Taghi Amiriani2; Majid Marjani 1; Abdoljalal Marjani 3 | ||||
1Faculty of Pharmacy, Eastern Mediterranean University, 99628, Famagusta, North Cyprus via Mersin 10, Turkey | ||||
2Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran | ||||
3Metabolic disorders research center, Biochemistry and Biophysics department, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Golestan Province, Iran. | ||||
Abstract | ||||
Studies on oral anti-hyperglycemic drugs have been shown in some studies to help and treat type 2 diabetic patients. The present study was designed to evaluate and compare the effect of different doses of metformin tablets on metabolic syndrome components in type 2 diabetic women in Gorgan, South East of Caspian Sea.Forty type 2 diabetic patients received 500 mg/day and 1000 mg/day metformin tablets for 12 months and forty healthy women were included in this study. The ATP III criteria were used to determine metabolic syndrome components, and lipid profiles, HbA1c and insulin were measured. Significant differences were found between blood sugar, triglycerides, high-density lipoprotein (HDL)-cholesterol, hemoglobin A1c (HbA1c) and insulin of the patients received 500 mg/day and 1000 mg/day metformin monotherapy. The blood sugar, triglycerides and insulin were significantly lower in patients received 500 and 1000 mg/day metformin than control groups. In both groups, HDL- cholesterol was higher than control groups, but HbA1c was significantly higher and lower in patients received 500 and 1000 mg/day metformin than control groups, respectively. In both study groups, positive significant correlation was found between blood glucose and HbA1c and, blood glucose and triglyceride levels. Our study showed the efficacy of the 1000 mg/day metformin monotherapy on better control of blood sugar, HbA1c, triglyceride and HDL- cholesterol levels, but Metformin had no effect on waist circumference and blood pressure. Treatment with this dose of metformin may be more beneficial for type 2 diabetic patients than those other doses. | ||||
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