PRE-SURGICAL USE OF MELATONIN AND ITS SIGNIFICANCE ON ENHANCING PROGNOSIS PROCESS IN PATIENTS UNDERGOING CARDIOPULMONARY BYPASS GRAFT | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 16, Volume 44, Issue 2, December 2021, Page 455-466 PDF (860.21 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.2021.207171 | ||||
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| Authors | ||||
Reza Jouybar1; Mansour Jannati  2; Saeed Khademi1
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| 1MD, Anesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran | ||||
| 2Cardiovascular Ward, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran | ||||
| Abstract | ||||
| One treatment choice for patients with coronary artery disease is coronary artery bypass graft surgery (CABG) with cardiopulmonary bypass (CPB). After CABG, a series of inflammatory processes occur which affect other organs of the body and even cause severe organ damage and subsequently a worse prognosis. The purpose of this study was to evaluate the effect of pre-surgically administered Melatonin (MTN) on interleukins 22 and 13 in patients undergoing CABG. In this clinical trial study, 22 patients were evaluated, 10 patients (45.5%) in the MTN group, and 12 patients in the placebo group. The MTN group received 10 mg/day of MTN and the placebo group received placebo 2 weeks before surgery. Serum interleukin 13 (IL- 13) and interleukin 22 (IL-22) levels were measured two weeks before surgery (T1), on the day of surgery before induction (T2), 6 hrs. after removal of the pump by the cardiac surgeon (T3), and 2 days after surgery (T4). The mean level of IL-22 at all time points in T2, T3, and T4 was significantly lower in the MTN group (P <0.05). There was also a significant increase in IL-22 in both groups at T4 compared to T1. The levels of IL-13 were also decreased, however, in the MTN group, the difference was only significant at T2 compared to T1 for IL-13. The current study found that taking melatonin for two weeks before having CABG can help to minimize inflammation and inflammatory biomarkers including IL-22 and IL-13 after the procedure. | ||||
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