ROLE OF MUCOSAL-ASSOCIATED INVARIANT T CELLS IN SYSTEMIC LUPUS ERYTHEMATOSUS | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 19, Volume 44, Issue 2, December 2021, Page 511-524 PDF (719.75 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.2021.207178 | ||||
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| Authors | ||||
rehab mekkawy 1; Omnia El-badawy2; Helal F. Hetta3, 4; Doaa K. Abd El-hafez5; Khaled M. Hassanein3
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| 1Forensic Medicine Authority, Ministry of Justice, Egypt. | ||||
| 2Medical Microbiology and Immunology Department, Faculty of Medicine, Assiut University, Assiut 71515, Egypt. | ||||
| 3Medical Microbiology and Immunology Department, Faculty of Medicine, Assiut University, Assiut 71515, Egypt | ||||
| 4Department of internal Medicine, College of Medicine, University of Cincinati, Cincinati, OH 45267-0595, USA. | ||||
| 5Physical Medicine, Rheumatology and Rehabilitation Department, Faculty of Medicine, Assiut University, Assiut, Egypt. | ||||
| Abstract | ||||
| The etiology of inflammatory and autoimmune diseases is complex and not yet fully understood. Their pathogenesis includes mechanisms in which both innate and adaptive immune cells are involved. Mucosal-associated invariant T (MAIT) cells are immune cells expressing an invariant TCRα chain (Vα7.2-Jα33 in human and Vα19-Jα33 in mice) and recognize the conserved MHC-I-related molecule MR1, which presents bacterial metabolites derived from the synthesis of vitamin B. Although most of the studies support a hazardous role of MAIT cells in tissue inflammation and destruction, few studies suggest a protective role. MAIT cells have tissue homing properties with the production of inflammatory cytokines, signifying that they may play an essential role in autoimmune and inflammatory diseases. In the current study, we clarified the present knowledge on MAIT cells in systemic lupus erythematosus. | ||||
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