DIFFERENTIAL CYTOKINE PROFILES IN PATIENTS WITH VIRAL AND NON-VIRAL RELATED LIVER CIRRHOSIS | ||||
| Bulletin of Pharmaceutical Sciences Assiut University | ||||
| Article 23, Volume 44, Issue 2, December 2021, Page 565-577 PDF (808.45 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bfsa.2021.207186 | ||||
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| Authors | ||||
| Sara A El-Mokhtar* 1; Omnia El-Badawy2; Helal F Hetta2; Mohamed O Abdel-Malek3; Noha A Afifi2 | ||||
| 1Department of Microbiology and Immunology, Faculty of Pharmacy, Assiut University, Assiut, Egypt | ||||
| 2Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut, Egypt | ||||
| 3Department of Tropical medicine and Gastroenterology, Faculty of Medicine, Assiut University, Assiut, Egypt | ||||
| Abstract | ||||
| Cytokines are pleiotropic peptides that are produced by nearly every nucleated cell in the human body. The liver is one of the most affected tissues. Hepatic inflammation, apoptosis and necrosis of liver cells, cholestasis, fibrosis, and cirrhosis are all mediated by cytokines. Interleukins (IL) like IL17 and IL10, the tumour necrosis factor (TNF) family of cytokines like TNF-α, chemokines like IL-8, and others are representing these cytokines. There is growing evidence that numerous cytokines play a key role in various aspects of liver disorders caused by viruses such as hepatitis C and B viruses, as well as non-viral liver diseases like autoimmune liver disease, Budd-Chiari syndrome, and other non-viral liver diseases. Biological response of cytokines involved in inflammation and cirrhosis may have an impact on the prognosis of certain disorders With respect to acute and chronic liver diseases. The present state of cytokine thoughts and functions in the pathogenesis of liver diseases, with a focus on liver cirrhosis, is discussed in this review. | ||||
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