H pylori eradication and strict diet regimen`s synergetic effect on glycemic state in type two diabetics on insulin therapy | ||||
| Middle East Journal of Therapeutic Nutrition and Complementary Medicine | ||||
| Article 1, Volume 1, Issue 1, April 2021, Page 23-29 PDF (1.11 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mejt.2021.14867.1006 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Ehab Kamal   1; Maha M. Saber2; Eitedal Daoud3; Mohamed AbdAllah 4; Hanan Ezelarab 5; Hazem El hariri6; Neveen A. Helmy7
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| 1Gastroenterology – Department of complementary medicine | ||||
| 2Head of complementary Medicine NRC- Medicine Pediatics Clinical nutrition | ||||
| 3professor of complementary medicine and nutritional therapy | ||||
| 4assistant researcher of tropical medicine medical research division national research centre | ||||
| 5Professor of Public Health -Faculty of Medicine - ASU - Pediatics - Clinical nutrition | ||||
| 6assitant researcher community medicine department national research centre | ||||
| 7Researcher at clinical and chemical pathology department, National research centre | ||||
| Abstract | ||||
| Abstract Helicobacter pylori (H. pylori) infection affects nearly 50% of the human population reaching an incidence rate of about 70% in developing countries. Egypt is one of the highest endemic areas for this infection. H. pylori infection is associated with gastro-intestinal and extra gastric diseases. Type two diabetes mellitus (T2DM) is the prevalent type of DM reaching about 90%, WHO predicting the number of patients to be 438 million by year 2030. Inflammation is the playing factor in the etiology of DM and insulin resistance. H pylori could be the source of infection. AIM To detect the effect of H pylori eradication on glycemic control in T2DM on insulin therapy with and without diet planning. METHODS A randomized controlled clinical trial involving 68 well known T2DM patients on insulin therapy proved H pylori positive by detection of antigens in the stool. Those patients were recruited from the outpatient clinics of the National Research Centre. The patients were randomized into 4 equal groups; Group 1 (M) received their routine medical treatment only, group 2 (MD) received medical treatment and individualized planned dietary regimen, group 3 (MH) received medical and anti-H pylori treatment while group 4 (MHD) received medical, anti-H pylori treatment and dietary regimen. Initial baseline evaluation included: diabetes panel, lipid profile, liver enzymes, renal functions and BMI which is repeated at the end of 6 months follow up. RESULTS A significant decrease of mean FBG, PPBG and HbA1c levels at the end of 6 months intervention from baseline levels in the 4 groups, however the mean difference increased from group 1 to group 4. Mean BMI and Uric acid significantly decreased in all groups except group-M. Cholesterol and triglycerides significantly decreased in all groups. Non-statistically significant changes regarding ALT, AST and serum creatinine were observed in all groups. | ||||
| Keywords | ||||
| H pylori; diabetes; nutrition | ||||
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