Role of Fluorine 18 Fluorodeoxyglucose (FDG) Positron Emission Tomography (PET)/Computed Tomography (CT) in Detection of Post-Thyroidectomy Recurrence in Differentiated Thyroid Cancer | ||||
| Benha Medical Journal | ||||
| Article 200, Volume 39, Special issue (Radiology), May and June 2022, Page 267-275 PDF (886.18 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bmfj.2021.96423.1486 | ||||
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| Authors | ||||
Amir Fathy Younis   1; Hamada Mohamed Khater2; Ahmed Farid Yousif3
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| 1Diagnostic and intervention radiology department, Naser institute for research and treatment , Cairo, Egypt. | ||||
| 2Radiodiagnosis department, Faculty of Medicine, Benha University, Benha, Egypt. | ||||
| 3Radiodiagnosis Department, Faculty of Medicine, Benha University , Benha, Egypt. | ||||
| Abstract | ||||
| Abstract: Aim/ learning objective: To demonstrate the role of 18F-FDG PET/CT for detection of post-thyroidectomy recurrence in differentiated cancer thyroid patients with negative radio-isotope iodine scan, yet showing elevated serum thyroglobulin level. Procedure: This is a prospective study which included 20 patients who had previous history of differentiated cancer thyroid. All patients after history taking and revising the medical sheet underwent Serum Thyroglobulin level Estimation & entire body scan I-131 (WBS) examination and then 18F-FDG PET/CT study. The findings of PET/CT imaging were compared with histopathology results or clinical follow-up results as a gold standard. Results: FDG PET/CT based analysis showed that 19 true positives and 1 was true negative as confirmed by the gold standard (Histopathology and clinical follow-up). 13 patients had either local recurrence or lymph node metastases without distant metastatic disease, 6 patients had different distant metastasis. 18F- FDG PET/CT based analysis showed that 19 true positives and 1 was true negative as confirmed by the gold standard (Histopathology and clinical follow-up). The sensitivity and accuracy of PET/CT (95%) were significantly better than those of the CT alone (84.2% and 80%, respectively) [P=0.03]. Conclusion: Combination between positron emission tomography (PET) and computed tomography (CT) allow anatomic, functional & molecular information. 18F-FDG PET/CT provided a critical role in assessment and management of patients with suspected differentiated thyroid recurrence, presenting with high serum thyroglobulin level and negative radio-isotope scan. The 18F-FDG PET/CT enhance diagnostic accuracy through giving exact anatomical localization of recurrent and/or metastatic tumor foci. | ||||
| Keywords | ||||
| Cancer thyroid; Fluorodeoxyglucose; thyroglobulin | ||||
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