Study of possible Cardioprotective Effect of Hydroxychloroquine Compared to Glimepiride and Metformin in Diabetic Rats
EL noury, H., Bahriz, A., Nasr, A., Khairy, A., Abd El Aziz, E. (2022). Study of possible Cardioprotective Effect of Hydroxychloroquine Compared to Glimepiride and Metformin in Diabetic Rats. EKB Journal Management System, 39(Special issue (Academic)), 96-110. doi: 10.21608/bmfj.2021.97405.1488
Heba EL noury; Ahmed Bahriz; Amany Nasr; Aya Khairy; Eman Abd El Aziz. "Study of possible Cardioprotective Effect of Hydroxychloroquine Compared to Glimepiride and Metformin in Diabetic Rats". EKB Journal Management System, 39, Special issue (Academic), 2022, 96-110. doi: 10.21608/bmfj.2021.97405.1488
EL noury, H., Bahriz, A., Nasr, A., Khairy, A., Abd El Aziz, E. (2022). 'Study of possible Cardioprotective Effect of Hydroxychloroquine Compared to Glimepiride and Metformin in Diabetic Rats', EKB Journal Management System, 39(Special issue (Academic)), pp. 96-110. doi: 10.21608/bmfj.2021.97405.1488
EL noury, H., Bahriz, A., Nasr, A., Khairy, A., Abd El Aziz, E. Study of possible Cardioprotective Effect of Hydroxychloroquine Compared to Glimepiride and Metformin in Diabetic Rats. EKB Journal Management System, 2022; 39(Special issue (Academic)): 96-110. doi: 10.21608/bmfj.2021.97405.1488

Study of possible Cardioprotective Effect of Hydroxychloroquine Compared to Glimepiride and Metformin in Diabetic Rats

Benha Medical Journal
Article 201, Volume 39, Special issue (Academic), September and October 2022, Page 96-110  XML PDF (1.23 MB)
Document Type: Original Article
DOI: 10.21608/bmfj.2021.97405.1488
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Authors
Heba EL noury1; Ahmed Bahriz2; Amany Nasr3; Aya Khairy email 4; Eman Abd El Aziz1
1Lecturer of Clinical Pharmacology, Faculty of Medicine, Benha University
2Clinical Pharmacology Faculty of Medicine, Banha University
3Ass. Professor of Clinical Pharmacology, Faculty of medicine, Benha University
4Demonstrator in the Department of Clinical Pharmacology, Faculty of medicine, kafr El-sheikh University.
Abstract
Background: Diabetes is associated with both micro- and macrovascular complications. Aim of the study: The aim of the present study is to evaluate the prophylactic effect of HCQ alone and in combination with glimepiride and metformin on ISO induced MI in type 2 diabetic rats. The present study included the parameters blood glucose, plasma insulin, HOMA-IR index, lipid profile, AKT, ECG changes and histopathology of the myocardium. Methods: Rats were classified into: Group I: control normal group. Group II: was not treated diabetic (diseased group). Group III: was treated with HCQ. Group IV: was treated with glimepiride. Group V: was treated with metformin. Group VI: was treated with HCQ + glimepiride. Group VII: was treated with HCQ + metformin. treated groups received drugs for 4 weeks. Results: Treated groups showed significant improvement in all parameters and improvement of the histopathology of the myocardium. A significant improvement in the parameters was seen in the treated groups at the end of the 4th week. Conclusion: Our study revealed that HCQ with glimepiride or with metformin produced more improvement in blood glucose level, insulin, HOMA-IR, lipid profile, AKT, ECG changes, histopathology of the myocardium. So, our drugs, mainly combined drugs may have a prophylactic effect against MI in diabetic rats. this may be due to their glycemic control and improvement of dyslipidemia.
Keywords
diabetes mellitus; myocardial infarction; HCQ; Glimepiride; metformin
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