Serum anti-tissue transglutaminase IgA antibodies in patients with psoriasis vulgaris and relation to its severity | ||
| Zagazig University Medical Journal | ||
| Article 12, Volume 30, Issue 1.2, January and February 2024, Pages 94-102 PDF (391.04 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zumj.2021.105754.2404 | ||
| Authors | ||
| Sawsan el Zayat1; Hassan Fayed2; Mona Gouida3; Marwa Zohdy* 4 | ||
| 1department of Dermatology, Mansoura Faculty of medicine, Mansoura University | ||
| 2Department of dermatology, Mansoura Faculty of Medicine, Mansoura University, Mansoura, Egypt | ||
| 3Mansoura University, Children Hospital, Genetic Department, Mansoura University, Egypt | ||
| 4Department of Dermatology, Mansoura faculty of Medicine, Mansoura University, Mansoura, Egypt | ||
| Abstract | ||
| Background: Psoriasis is a common skin disease associated with different co-morbidities. High serum levels of anti-tissue transglutaminase-2 IgA (TTG-IgA), produced and deposited in the intestine, characterizes celiac disease. Recently, an elevation in TTG-IgA antibodies in psoriatic cases was reported, compared to non-psoriatics. Objective: The aim of the current study was to compare the level of anti-tissue transglutaminase IgA in psoriatic patients versus non-psoriatic control group and to find a possible relation with disease severity. Methods: This was a case-control study conducted on 45 patients with psoriasis who attended the outpatient clinic of Dermatology, Andrology & STDs Department of Mansoura University Hospitals, and 45 age and sex matched completely healthy people. Results: Psoriatic cases demonstrated a significant increase in TTG-IgA serum levels compared to non-psoriatic controls. GIT manifestations were prevalent among psoriatic cases and were related positively to the degree of psoriasis activity (PASI score). TTG-IgA concentration showed excellent value in differentiating psoriatic cases from controls. TTG-IgA demonstrated as a significant positive correlation with PASI score among psoriatic cases. Conclusion: TTG-IgA concentration could be used as a significant predictor for psoriasis as well as its severity. | ||
| Keywords | ||
| Anti-tissue transglutaminase IgA antibodies; Celiac disease; PASI score; Psoriasis | ||
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