Alpha 1 Acid Glycoprotein as a Marker for Diagnosis of Early-Onset Neonatal Sepsis in Full-term Neonates | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 126, Volume 85, Issue 2, October 2021, Page 4218-4222 PDF (482.54 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2021.208085 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Gameel Hassan Mansor  ; Azza Ali Khalil; Safaa Hamdy Ahmad; Naglaa Ali KHalifa
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| Abstract | ||||
| Background: Neonatal sepsis is defined as a clinical syndrome of bacteremia with systemic signs and symptoms of infection in the first 4 weeks of life. Alpha-1 acid glycoprotein is one of the lipocalin family and members of acute-phase protein; it appears to function in modulating the activity of the immune system during the acute phase reaction. Objective: This study aimed to assess α-1AGP as a marker in the diagnosis of EOS. Patients and Methods: This study was a prospective case-control study conducted on full-term neonates up to 7 days of life, admitted to the neonatal intensive care unit of Zagazig University Hospitals. The studied neonates were divided into 3 groups first confirmed cases (20) of early-onset sepsis, confirmed clinically and with a positive blood culture. Second suspected cases (20), with clinical features of sepsis and non-specific lab markers. Third group control (20), are apparently healthy term newborns, delivered in the Zagazig University Hospital. Alpha-1 acid glycoprotein was measured for all neonates. Results: There was a statistically significant difference among the studied groups as regard alpha one acid glycoprotein. It is a good diagnostic marker detection of cases. Conclusion: Alpha-1-acid glycoprotein appeared to be a useful marker for the early detection and diagnosis of early-onset neonatal sepsis. | ||||
| Keywords | ||||
| Alpha 1 Acid Glycoprotein; Early Onset Neonatal Sepsis; Fullterm Neonates Diagnosis | ||||
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