Synthesis, Characterization, Theoretical Study, Antioxidant Activity and in Vitro Cytotoxicity Study of Novel Formazan Derivatives Toward MCF-7 Cells | ||||
Egyptian Journal of Chemistry | ||||
Article 17, Volume 65, Issue 6, June 2022, Page 181-188 PDF (690.5 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/ejchem.2021.100236.4659 | ||||
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Authors | ||||
Hasanain Gomhor J. Alqaraghuli 1; Zainab Y. Kadhim 2; Ameena N. Seewan3 | ||||
1Department of Sciences, College of Basic Education, Al-Muthanna University. | ||||
2College of Veterinary Medicine, Al-Muthanna University, Al-Muthanna, Iraq. | ||||
3Department of Sciences, College of Basic Education, Al-Muthanna University, Al-Muthanna, Iraq. | ||||
Abstract | ||||
New formazan derivatives F-1 and F-2 were synthesized and tested as antioxidant and anticancer agents. Chemical structures of compounds were proved by spectroscopic methods (FT-IR, 1H-NMR and GC-Mass) and elemental analysis (CHN). The cytotoxicity activity of formazan derivatives was estimated against human breast cancer (MCF-7) cells. The synthesized compounds exhibited significant cytotoxic activity toward MCF-7 cell lines. Compound F-1 showed the highest toxicity toward MCF-7 cells. MTT assay demonstrated that 16 µg/ml of compound F-1 reduced cell growth by 88.33%, after 48 hours. Hemolysis study demonstrated that the hemolysis percentage of compounds F-1 and F-2 at (10 mg/ml) concentration was (4.05% to 4.18%), this result indicates the safety of their use inside the body. The antioxidant activity of the formazan compounds against DPPH radicals was tested in vitro. The results displayed that compound F-1 has stronger antioxidant activity than compound F-2. The new compounds were investigated in the gas phase using HyperChem software, applying semi-empirical methods and molecular mechanics. The heat of formation, binding energy, HOMO-LUMO, energy gab and dipole moment were calculated, and the results showed that compound F-1 was more stable and more polar than F-2. | ||||
Keywords | ||||
Formazan derivatives; breast cancer; anticancer activity; theoretical study and MCF-7 | ||||
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