The role of IMP3 and BCL2 in differentiating between irritated seborrheic keratosis, insitu and invasive squamous cell carcinomas of the skin
bassyoni, O., Emara, N., rashad, H. (2022). The role of IMP3 and BCL2 in differentiating between irritated seborrheic keratosis, insitu and invasive squamous cell carcinomas of the skin. EKB Journal Management System, 39(Special issue (Radiology)), 210-219. doi: 10.21608/bmfj.2021.87517.1446
omneya youssef bassyoni; Nashwa Mohamed Emara; heba Mohamed rashad. "The role of IMP3 and BCL2 in differentiating between irritated seborrheic keratosis, insitu and invasive squamous cell carcinomas of the skin". EKB Journal Management System, 39, Special issue (Radiology), 2022, 210-219. doi: 10.21608/bmfj.2021.87517.1446
bassyoni, O., Emara, N., rashad, H. (2022). 'The role of IMP3 and BCL2 in differentiating between irritated seborrheic keratosis, insitu and invasive squamous cell carcinomas of the skin', EKB Journal Management System, 39(Special issue (Radiology)), pp. 210-219. doi: 10.21608/bmfj.2021.87517.1446
bassyoni, O., Emara, N., rashad, H. The role of IMP3 and BCL2 in differentiating between irritated seborrheic keratosis, insitu and invasive squamous cell carcinomas of the skin. EKB Journal Management System, 2022; 39(Special issue (Radiology)): 210-219. doi: 10.21608/bmfj.2021.87517.1446

The role of IMP3 and BCL2 in differentiating between irritated seborrheic keratosis, insitu and invasive squamous cell carcinomas of the skin

Benha Medical Journal
Article 18, Volume 39, Special issue (Radiology), May and June 2022, Page 210-219  XML PDF (1.33 MB)
Document Type: Original Article
DOI: 10.21608/bmfj.2021.87517.1446
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Authors
omneya youssef bassyoni email 1; Nashwa Mohamed Emara2; heba Mohamed rashad3
1department of pathology ,f aculty of medicine ,Benha univeristy
2Department of Pathology,Faculty of Medicine, BenhaUniversity, Egypt.
3lecturer at pathology department, Benha faculty of medicine, Benha
Abstract
Introduction: The histological distinction between squamous cell carcinoma both in-situ and invasive from their benign mimic; irritated seborrheic keratosis is still a difficulty. The aim of this study is to invistigate the diagnostic utility of Insulin-like growth factor II mRNA-binding protein 3 (IMP3), and B-cell lymphoma 2 (BCL2 ) in differentiating forementioned cutaneous tumors.
Materials and Methods: This is a retrospective study to include 50 cases , 25(50%) cases of squamous cell carcinoma (SCC), 10 (20%) cases of squamous cell carcinoma in-situ (SCCIS), and 15 (30%) cases of irradiated seborrheic keratosis (ISK) . The immunohistochemical expression of IMP3and BCL2 was studied .
Results: BCL2 was expressed in 12/15(80%) ISK cases compared to 3/10 (30%) in SCCIS and 4/25 (16%) in invasive SCC cases (p < /p>
Keywords
irritated seborrheic keratosis; squamous cell carcinoma; IMP3; BCL2
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