Molecular and Biochemical Studies on Some Natural Compounds and Their Effect on the Streptozotocin-induced Diabetic Rats and Their Role in Treatment | ||||
Journal of Bioscience and Applied Research | ||||
Article 6, Volume 7, Issue 4, December 2021, Page 160-175 PDF (584.26 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/jbaar.2021.208849 | ||||
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Authors | ||||
Adel Abaskharon Guirgis1; Dawoud Fakhry Habib2; Hanan Hanna3; Ramy Abosaif Mahmoud* 1 | ||||
1Molecular Biology Department, Genetic Engineering &Biotechnology Research Institute University of Sadat City, Egypt | ||||
2Clinical Biochemistry Department, National Research Centre (NRC), Egypt | ||||
3Chemical Pathology Department, Faculty of Physical Therapy, Pharos University in Alexandria, Egypt | ||||
Abstract | ||||
Background: The number of individuals with diabetes mellitus (DM) worldwide has more than doubled over the past three decades, and it has been predicted that the number of diabetic patients would increase to 439 million by 2030, so many efforts are being made to find a new and effective treatment for diabetes mellitus. Objective: This work aims to study the biochemical and molecular effect of the Moringa oleifera MO and Ficus sycomorus FLE in streptozotocin-induced diabetic rats and compare them with the effect of metformin, by estimation of the expression of β-actin and glucose transporter GLUT2, GLUT4, and Insulin Receptors genes in studied groups, Determination of fasting blood glucose and insulin levels before and after induction of (STZ), Quantitative estimation serum cholesterol, TG levels, HDL, LDL, Some antioxidant enzyme activity Glutathione peroxidase, catalase and lipid peroxidation in plasma. Results: MO and FLEshowed promising anti-diabetic potential in diabetic-bearing albino mice which can be attributed to its anti-inflammatory effect. This could serve as a stepping stone towards the discovery of newer safe and effective anti-diabetic treatment. | ||||
Keywords | ||||
Streptozotocin; anti-diabetic; metformin; Gene expression studies | ||||
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