Chemical Composition, Antioxidant, Antitumor and Antifungal Activities of Methanolic Extracts of Coleus blumei, Plectranthus amboinicus and Salvia splendens (Lamiaceae)
Taher, M., El-Daly, N., El-Khateeb, A., Hassan, S., Elsherbiny, E. (2021). Chemical Composition, Antioxidant, Antitumor and Antifungal Activities of Methanolic Extracts of Coleus blumei, Plectranthus amboinicus and Salvia splendens (Lamiaceae). EKB Journal Management System, 12(11), 177-187. doi: 10.21608/jacb.2021.209208
M. Taher; Nourhan M. El-Daly; A. Y. El-Khateeb; Safaa M. Hassan; E.A. Elsherbiny. "Chemical Composition, Antioxidant, Antitumor and Antifungal Activities of Methanolic Extracts of Coleus blumei, Plectranthus amboinicus and Salvia splendens (Lamiaceae)". EKB Journal Management System, 12, 11, 2021, 177-187. doi: 10.21608/jacb.2021.209208
Taher, M., El-Daly, N., El-Khateeb, A., Hassan, S., Elsherbiny, E. (2021). 'Chemical Composition, Antioxidant, Antitumor and Antifungal Activities of Methanolic Extracts of Coleus blumei, Plectranthus amboinicus and Salvia splendens (Lamiaceae)', EKB Journal Management System, 12(11), pp. 177-187. doi: 10.21608/jacb.2021.209208
Taher, M., El-Daly, N., El-Khateeb, A., Hassan, S., Elsherbiny, E. Chemical Composition, Antioxidant, Antitumor and Antifungal Activities of Methanolic Extracts of Coleus blumei, Plectranthus amboinicus and Salvia splendens (Lamiaceae). EKB Journal Management System, 2021; 12(11): 177-187. doi: 10.21608/jacb.2021.209208

Chemical Composition, Antioxidant, Antitumor and Antifungal Activities of Methanolic Extracts of Coleus blumei, Plectranthus amboinicus and Salvia splendens (Lamiaceae)

Journal of Agricultural Chemistry and Biotechnology
Article 1, Volume 12, Issue 11, November 2021, Page 177-187  XML PDF (1.1 MB)
Document Type: Original Article
DOI: 10.21608/jacb.2021.209208
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Authors
M. Taher email orcid 1; Nourhan M. El-Daly2; A. Y. El-Khateeb2; Safaa M. Hassan2; E.A. Elsherbiny3
1Department of Agricultural Chemistry, Faculty of Agriculture, Mansoura University, Mansoura, 33516, Egypt.
2Agricultural Chemistry Department, Faculty of Agriculture, Mansoura University, Mansoura 35516, Egypt
3Plant Pathology Department, Faculty of Agriculture, Mansoura University, Mansoura 35516, Egypt
Abstract
The present study aims to elucidate the chemical characterization of the methanolic extracts of Coleus blumei, Plectranthus amboinicus, and Salvia splendens with emphasis on their antioxidant, antifungal, and cytotoxic activities. Among all methanolic extracts, P. amboinicus extract containsthe highest contents of the total polyphenols and total flavonoids by 122.2 g GAE Kg-1 and 41.4 g QE Kg-1, respectively. Rosmarinic acid (1.021 g Kg-1) was the predominant phenol in P. amboinicus according to HPLC analysis. Carvacrol was the predominant component (7.59%) of P.amboinicus extract by GC-MS analysis. The extract of P. amboinicus recorded the lowest IC50 and EC50 values for DPPH and reducing power by 0.042 g L-1, and 0.327 g L-1, respectively, indicating the greatest antioxidant potential. Also, P. amboinicus showed the highest antitumor activity using A549, MCF7, and HEPG cell lines with IC50 values by 0.041, 0.047 and 0.043 g L-1, respectively. Theextract of S. splendens showed a remarkable selectivity toward MCF7 cell line with IC50 valueby 0.040 g L-1.The methanol extract of P. amboinicus displayed the greatest inhibition on the mycelial growth of Sclerotinia sclerotiorum (83.0 %), Cochliobolus cynodontis (82.1 %), Botrytis cinerea(77.8 %), Bipolaris hawaiensis (74.1 %), B. spicifera (73.9 %), and Alternaria alternata (73.7 %) at the concentration of 32 g L-1.
Keywords
DPPH; flavonoids content; GC-MS; HPLC; polyphenols content; reducing power (RP)
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