The outcome of the sofosbuvir Based Therapy in the treatment of Hepatitis C Virus Genotype 4 in Egyptian patients | ||||
| African Journal of Gastroenterology and Hepatology | ||||
| Article 1, Volume 2, Issue 1, February 2019, Page 1-18 PDF (429.17 K) | ||||
| Document Type: Original Clinical | ||||
| DOI: https://dx.doi.org/10.52378/alkj/2738 | ||||
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| Authors | ||||
Waleed Abdul Fattah Ismail1; Amr Shaaban Hanafy   2; Mohammed Abdelsattar3
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| 1Assistant professor of internal medicine, gastroenterology and hepatology unit, faculty of medicine, Zagazig University | ||||
| 2Internal Medicine Department, Hepatogastroenterology Unit – Zagazig University. Egypt | ||||
| 3Internal Medicine Department- Mansura University | ||||
| Abstract | ||||
| Background and aim There have been significant advancements during the last few years, with large numbers of ongoing trials with various direct-acting antivirals (DAA) showing high potency against the hepatitis C virus (HCV). The aim was to show the effectiveness and side effects of Sofosbuvir-based therapy in treating HCV genotype 4 in Egyptian patients and compare its results with the international results. Methods The study included 740 patients with chronic HCV. The study population consisted of three groups: Group (1): included 240 patients treated with sofosbuvir 400 mg plus Peginterferon α2a and weight-based ribavirin for 12 weeks. Group (2): had 250 patients treated with sofosbuvir 400 mg and weight-based ribavirin for 24 weeks. Group (3): involved 250 patients treated with sofosbuvir 400 mg and simeprevir 150 mg once daily for 12weeks. Results Sustained virological response (SVR) occurred in 83.3% of the triple therapy group. In the dual therapy group, SVR occurred in 64% of patients. In the Simeprevir-Sofosbuvir group, SVR was achieved in 96% of patients, with statistically significant differences among the studied groups (p=0.015). Multivariate logistic regression analysis showed that treatment with simeprevir and sofosbuvir was associated with higher rates of SVR with an odds ratio of 12.5. Serum creatinine shows a negative correlation with an odds ratio of 3.1; MELD score showed a negative correlation with an odds ratio of 1.5. Conclusion Sofosbuvir-based therapy has satisfactory results for the treatment of hepatitis C virus genotype 4 with lesser complications | ||||
| Keywords | ||||
| Outcome; sofosbuvir Based Therapy; Hepatitis C Virus; genotype 4; Egyptians | ||||
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