Targeted drug delivery of capecitabine to mice xenograft gastric cancer by PAMAM dendrimer nanocarrier | ||||
African Journal of Gastroenterology and Hepatology | ||||
Article 3, Volume 2, Issue 1, February 2019, Page 30-55 PDF (747.04 K) | ||||
Document Type: Original Clinical | ||||
DOI: https://dx.doi.org/10.52378/fkh195276 | ||||
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Authors | ||||
Sharareh Jafari1, 2; Fatemeh Nabavizadeh 2; Jalal Vahedian3; Mehdi Shafie Ardestani4; Hedayat Samandari1; Ali Zare Mehrjerdi5 | ||||
1Electrophysiology Research Center, Neurosciences Institute, Tehran University of Medical Sciences, Tehran, Iran | ||||
2Department of Physiology, Medical school, Tehran University of Medical Sciences, Tehran, Iran | ||||
3Department of Surgery, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran | ||||
4Department of Radiopharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran | ||||
5Department of Pathology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran | ||||
Abstract | ||||
Aims: This study used an animal xenograft model of gastric cancer induction to investigate the therapeutic effects of capecitabine polyamidoamine (PAMAM) dendrimer complex against cancer and its potential side effects. Methods and Materials: Human gastric cancer tissue was obtained from patients with gastric carcinoma and transplanted into mice. Anticancer drug capecitabine was loaded into PAMAM dendrimer nano-carrier and injected into the animals. All animals received cyclosporine before the surgery. Results: Capecitabine-dendrimer complex reduced the size of the axillary implanted tumor, the levels of AST and ALP, and the drug-induced adverse effects on other body organs. Furthermore, it increased apoptotic and necrotic responses in the grafted tumor, RBC, WBC, and platelet counts compared to free capecitabine. Conclusions: In gastric cancer settings, the PAMAM dendrimer drug delivery method effectively improved therapeutic index and outcomes and reduced undesirable side-effects of the capecitabine. | ||||
Keywords | ||||
Gastric cancer; Xenograft; Capecitabine; Cyclosporine; Poly amidoamine dendrimer (PAMAM); Mice | ||||
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