Salivary Surfactant Protein D as a Biomarker of Asthma Severity In Preschool Children.
Yousif, Y., Elbehidy, R., Hanafee, A., Abd elnour, H., Gehad, M. (2023). Salivary Surfactant Protein D as a Biomarker of Asthma Severity In Preschool Children.. EKB Journal Management System, 29(3), 859-863. doi: 10.21608/zumj.2021.107548.2415
Yousif Mohamed Yousif; Rabab Elbehidy; Ahmed Hassan Hanafee; Hanim Magdy Abd elnour; Mona Hamed Gehad. "Salivary Surfactant Protein D as a Biomarker of Asthma Severity In Preschool Children.". EKB Journal Management System, 29, 3, 2023, 859-863. doi: 10.21608/zumj.2021.107548.2415
Yousif, Y., Elbehidy, R., Hanafee, A., Abd elnour, H., Gehad, M. (2023). 'Salivary Surfactant Protein D as a Biomarker of Asthma Severity In Preschool Children.', EKB Journal Management System, 29(3), pp. 859-863. doi: 10.21608/zumj.2021.107548.2415
Yousif, Y., Elbehidy, R., Hanafee, A., Abd elnour, H., Gehad, M. Salivary Surfactant Protein D as a Biomarker of Asthma Severity In Preschool Children.. EKB Journal Management System, 2023; 29(3): 859-863. doi: 10.21608/zumj.2021.107548.2415

Salivary Surfactant Protein D as a Biomarker of Asthma Severity In Preschool Children.

Zagazig University Medical Journal
Article 14, Volume 29, Issue 3, May and June 2023, Page 859-863  XML PDF (357.36 K)
Document Type: Original Article
DOI: 10.21608/zumj.2021.107548.2415
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Authors
Yousif Mohamed Yousif1; Rabab Elbehidy2; Ahmed Hassan Hanafee2; Hanim Magdy Abd elnour3; Mona Hamed Gehad email orcid 4
1pediatric department, faculty of medicine, zagazig university, sharkia , Egypt.
2Department of pediatrics, Faculty of medicine, Zagazig University, Sharkia, Egypt
3medical biochmestry and molecular biology department, faculty of medicine, Zagazig univerisity, Zagazig, Egypt
4Pediatric department zagazig university hospitals
Abstract
Background : Surfactant protein D (SP D) is crucial in controlling the immunological response of the peripheral airways, Surfactant changes caused by airway inflammation may have a role in the pathophysiology of asthma.
Aim of this study: was to assess the value of salivary SP D in Preschool asthmatic children .
Methods: in our case control study including 30 non-asthmatic controls and 30 preschool asthmatic children aged 2-5 years old, we assessed salivary SP D and pulmonary functions using impulse oscillometry (IOS) then the correlations between salivary SP D levels and IOS indices were analyzed.
Results: Salivary SP D levels were increased in asthmatic group with mean ± SD of 32.52±12.88 pg/ml compared to 5.98±2.87 pg/ml in healthy controls. Moreover, it was correlated with poor pulmonary functions using IOS indices with cutoff expression value of SP D >8.19 using ROC curve at the optimal sensitivity 83.3% and specificity 81.0% to differentiate asthmatic children from controls.
Conclusion: Salivary SP D can be a useful marker for childhood asthma and can monitor deterioration in pulmonary functions in preschool asthmatic children.
Keywords
Keywords: Bronchial asthma; Surfactant protein D; Pediatrics; Impulse oscillometry
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