Salivary Surfactant Protein D as a Biomarker of Asthma Severity In Preschool Children. | ||||
Zagazig University Medical Journal | ||||
Article 14, Volume 29, Issue 3, May and June 2023, Page 859-863 PDF (357.36 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/zumj.2021.107548.2415 | ||||
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Authors | ||||
Yousif Mohamed Yousif1; Rabab Elbehidy2; Ahmed Hassan Hanafee2; Hanim Magdy Abd elnour3; Mona Hamed Gehad 4 | ||||
1pediatric department, faculty of medicine, zagazig university, sharkia , Egypt. | ||||
2Department of pediatrics, Faculty of medicine, Zagazig University, Sharkia, Egypt | ||||
3medical biochmestry and molecular biology department, faculty of medicine, Zagazig univerisity, Zagazig, Egypt | ||||
4Pediatric department zagazig university hospitals | ||||
Abstract | ||||
Background : Surfactant protein D (SP D) is crucial in controlling the immunological response of the peripheral airways, Surfactant changes caused by airway inflammation may have a role in the pathophysiology of asthma. Aim of this study: was to assess the value of salivary SP D in Preschool asthmatic children . Methods: in our case control study including 30 non-asthmatic controls and 30 preschool asthmatic children aged 2-5 years old, we assessed salivary SP D and pulmonary functions using impulse oscillometry (IOS) then the correlations between salivary SP D levels and IOS indices were analyzed. Results: Salivary SP D levels were increased in asthmatic group with mean ± SD of 32.52±12.88 pg/ml compared to 5.98±2.87 pg/ml in healthy controls. Moreover, it was correlated with poor pulmonary functions using IOS indices with cutoff expression value of SP D >8.19 using ROC curve at the optimal sensitivity 83.3% and specificity 81.0% to differentiate asthmatic children from controls. Conclusion: Salivary SP D can be a useful marker for childhood asthma and can monitor deterioration in pulmonary functions in preschool asthmatic children. | ||||
Keywords | ||||
Keywords: Bronchial asthma; Surfactant protein D; Pediatrics; Impulse oscillometry | ||||
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