Early complications in adult liver transplant recipients at the Wits Donald Gordon Medical Centre, South Africa
Chiba, S., Lowman, W., Schleicher, G. (2020). Early complications in adult liver transplant recipients at the Wits Donald Gordon Medical Centre, South Africa. EKB Journal Management System, 3(1), 1-24. doi: 10.52378/hmer7639
Sheetal Chiba; Warren Lowman; Gunter Schleicher. "Early complications in adult liver transplant recipients at the Wits Donald Gordon Medical Centre, South Africa". EKB Journal Management System, 3, 1, 2020, 1-24. doi: 10.52378/hmer7639
Chiba, S., Lowman, W., Schleicher, G. (2020). 'Early complications in adult liver transplant recipients at the Wits Donald Gordon Medical Centre, South Africa', EKB Journal Management System, 3(1), pp. 1-24. doi: 10.52378/hmer7639
Chiba, S., Lowman, W., Schleicher, G. Early complications in adult liver transplant recipients at the Wits Donald Gordon Medical Centre, South Africa. EKB Journal Management System, 2020; 3(1): 1-24. doi: 10.52378/hmer7639

Early complications in adult liver transplant recipients at the Wits Donald Gordon Medical Centre, South Africa

African Journal of Gastroenterology and Hepatology
Volume 3, Issue 1, July 2020, Page 1-24  XML PDF (438.05 K)
Document Type: Original Clinical
DOI: 10.52378/hmer7639
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Authors
Sheetal Chiba email 1; Warren Lowman2; Gunter Schleicher3
1University of the Witwatersrand, Department of Internal Medicine, Johannesburg, South Africa
2Vermaak and Partners/ Pathcare Pathologists, Johannesburg, South Africa: Wits Donald Gordon Medical Centre Parktown, South Africa
3Wits Donald Gordon Medical Centre ICU, Parktown, South Africa.
Abstract
Background
Deceased donor liver transplantation (DDLT) is a transplant modality performed routinely in adults at Wits Donald Gordon Medical Centre (WDGMC). Infection, graft dysfunction, surgical and medical complications are common in the early post-transplant period, accounting for early15 morbidity and mortality.
Objectives
To provide a descriptive analysis of all complications in the first 30 days post DDLT.
To investigate associations between recipient demographic data, comorbid diabetes, MELD score, and subsequent complications.
Methods
A retrospective review of adult DDLT recipients for the first 30 days post-transplant was performed at WDGMC from January 2015 - December 2016. Fischer's exact test was used to assess relationships between demographic data and infectious complications, while an independent sample t-test was used for non-infectious complications.
Results
Seventy-eight DDLTs were performed, with 6 (8%) mortalities in the first 30 days. The median age was 54 years; 54% were male. In total, 24 recipients (31%) developed infectious complications. Sixteen patients (67% of the infectious cohort) had intra-abdominal sepsis, 6 (25%) developed lower respiratory tract infections, 6 (25%) skin and soft tissue infections, and 3 (13%) urinary tract infections. Of all infectious complications, seven patients (29%) developed bacteremia. Non-infectious complications were developed in 55 patients (71%); renal complications were more common (67%). There was no significant association between age, gender, ascites, diabetes mellitus, MELD score, and complications.
Conclusion
Non-infectious complications were more prominent than infectious complications in adult recipients in the first 30 days post-DDLT. There was no significant association between recipient demographic data, comorbid diabetes, CMV status, and MELD score.
Keywords
Early complications; liver transplant recipients; Deceased donor liver transplantation; Wits Donald Gordon Medical Centre; Model for End-Stage Liver Disease
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