PERSPECTIVES ON TOLERANCE TO PARASITIC INFECTIOUS DISEASES | ||||
| Journal of the Egyptian Society of Parasitology | ||||
| Article 7, Volume 51, Issue 3, December 2021, Page 485-492 PDF (711.44 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jesp.2021.210426 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| MARWA A. HASSAN; MOUSA A. MOUSA ISMAIL | ||||
| Department of Medical Parasitology, Faculty of Medicine, Cairo University, Cairo, Egypt | ||||
| Abstract | ||||
| Immune responses to infectious parasitic diseases appear to be simply directed towards killing or clearing the parasite. However, the immunological strategies constitute a complex incorporated network of immune mechanisms to eradicate the parasite itself in addition to preservation of the integrity of host tissues. Resistance and tolerance are believed to be two distinct complementary host defense immune strategies. Mechanisms triggering infectious tolerance to parasitic infections are still poorly recognized but seem to be centered on controlling parasiteinduced tissue damage in the infected host. It is becoming obvious that realizing infectious tolerance as a prominent constituent of defense strategy deliver significant conceptions in coexistence of host-parasite relationship. This data may also pave the way to new therapeutic approaches in many parasitosis. | ||||
| Keywords | ||||
| Immune response; Tolerance; Parasitic infections; Resistance; Review | ||||
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