Potential Reno-Protective Effect of Dexmedetomidine Versus N. Acetylcysteine Among Patients Undergoing Cardiac Surgery | ||||
| SVU-International Journal of Medical Sciences | ||||
| Article 25, Volume 5, Issue 1, January 2022, Page 226-239 PDF (348.06 K) | ||||
| Document Type: Original research articles | ||||
| DOI: 10.21608/svuijm.2021.105368.1240 | ||||
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| Authors | ||||
Mohamed Elzouk Oraby  1; Salah Mostafa Asida1; Hatem Saber Mohamed1; Ahmed Yosof Ahmed Abdel Zaher1; Abdallah Elaiw Mohamed Ali2
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| 1Department of Anesthesia, ICU and Pain management, Faculty of Medicine, South Valley University, Qena, Egypt | ||||
| 2Department of Clinical and Chemical Pathology, ICU and Pain management, Faculty of Medicine, South Valley University, Qena, Egypt | ||||
| Abstract | ||||
| Background: Acute kidney injury (AKI) is one of the severe complications after cardiac surgeries, raising morbidities and mortalities. Objectives: The study aimed to compare the potential reno-protective effect of continuous I.V infusion of Dexmedetomidine (DEX) and N-Acetylcysteine (NAC) among cases undergoing Cardiac surgeries. Patients and Methods: This randomized, double-blind, placebo-controlled trial was done at Qena University Hospitals and Sohag Cardiac Institute in period between October 2019 to October 2021, including 90 cases listed for elective on pump open-heart surgeries. Results: Regarding Urine Output(UOP), the DEX group showed a significantly higher UOP value than both NAC and placebo groups at day 1 postoperatively. Still on day 2 postoperatively, the DEX group showed a statistically significant higher UOP value than the placebo group only. Also, there were non-statistically significant differences between pre-operative and postoperative values in each group (between basal and final values). Regarding urinaryNeutrophil Gelatinase-associated Lipocalin (NGAL), there were non-statistically significant differences between groups at baseline, but the DEX group showed a significantly lower NGAL values than the placebo group at T1 and T2 postoperatively. Also, there were statistically significant differences between pre-operative and postoperative values in all groups.DEX group showed significantly lower postoperative AKI incidencethan placebo group. Conclusion: DEX could have a more reno-protective effect among patients undergoing cardiac surgery than N-acetylcysteine or placebo. This was demonstrated by lower urinary NGAL level, raised UOP, and lower postoperative AKI among cases treated with DEX. | ||||
| Keywords | ||||
| Acute kidney injury; Dexmedetomidine; N-Acetylcysteine; Cardiac | ||||
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