Mohamed Abd El-Maksoud, N., Abulsoud, A., Abulsoud, M., Elshaer, S. (2022). Association between vitamin D receptor gene polymorphism and osteoporotic fractures among type II diabetic Egyptian females. EKB Journal Management System, 2(1), 12-19. doi: 10.21608/aijpms.2021.67306.1054
Nourhan Mohamed Abd El-Maksoud; Ahmed Abulsoud; Mohamed Abulsoud; Shereen Elshaer. "Association between vitamin D receptor gene polymorphism and osteoporotic fractures among type II diabetic Egyptian females". EKB Journal Management System, 2, 1, 2022, 12-19. doi: 10.21608/aijpms.2021.67306.1054
Mohamed Abd El-Maksoud, N., Abulsoud, A., Abulsoud, M., Elshaer, S. (2022). 'Association between vitamin D receptor gene polymorphism and osteoporotic fractures among type II diabetic Egyptian females', EKB Journal Management System, 2(1), pp. 12-19. doi: 10.21608/aijpms.2021.67306.1054
Mohamed Abd El-Maksoud, N., Abulsoud, A., Abulsoud, M., Elshaer, S. Association between vitamin D receptor gene polymorphism and osteoporotic fractures among type II diabetic Egyptian females. EKB Journal Management System, 2022; 2(1): 12-19. doi: 10.21608/aijpms.2021.67306.1054
Association between vitamin D receptor gene polymorphism and osteoporotic fractures among type II diabetic Egyptian females
Azhar International Journal of Pharmaceutical and Medical Sciences
1Department of Biochemistry, faculty of pharmacy, Heliopolis University, Egypt
2Department of Biochemistry, Faculty of pharmacy, Al-Azhar University (Boys), Cairo, Egypt
3Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo, Egypt
4Department of Orthopaedic Surgery, Faculty of Medicine (Boys), Al-Azhar University, Cairo, Egypt
5Department of Biochemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt
6Department of Biochemistry, Faculty of Pharmacy, Heliopolis University, Cairo, Egypt.
Abstract
The central role of the biologically active vitamin D is to regulate calcium homeostasis through increasing bone mineralization and intestinal calcium absorption. Moreover, vitamin D is found to be related to glucose metabolism, therefore vitamin D deficiency and vitamin D receptor (VDR) gene polymorphism may provoke type 2 diabetes mellitus (T2DM) and osteoporotic fractures as well. This case control study was conducted on 90 premenopausal females. Serum vitamin D2, total calcium, albumin, ionized calcium and fasting plasma glucose were assayed. VDR gene TaqI single nucleotide polymorphism was assessed using polymerase chain reaction (PCR) using DNA isolated from the collected whole blood. Results showed that hyperglycemia, hypovitaminosis D2 and low level of total calcium were observed in secondary T2DM osteoporotic fractures. G allele was significant in the control group compared to patients with secondary T2DM osteoporotic fractures. Accordingly, we deduce that the recessive G allele has a protective role against osteoporotic fractures in T2DM females.