Characterization of Epidemiological, Clinical, Histopathological and Nutritional Profile of Female Breast Cancer in Western Algeria: About A Case-Control Study | ||||
| Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology | ||||
| Article 20, Volume 13, Issue 2, December 2021, Page 249-263 PDF (872.25 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/eajbsc.2021.210709 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Zeggai Souad1; Moulessehoul Soraya2; Tiboura Ghania1; Hamri Walid1; Miche Khalida2; Mehyaoui Imane2 | ||||
| 1Laboratory of Nutrition, Pathology, Agro Biotechnology and Health, Department of Biology, Faculty of Life Sciences, Djillali Liabes. 12 Rue Oulhaci Mokhtar. University of Sidi Bel Abbes, Algeria. | ||||
| 2Laboratory of Biotoxicology, Department of Biology, Faculty of Life Sciences, Djillali Liabes. 12 Rue Oulhaci Mokhtar. University of Sidi Bel Abbes, Algeria | ||||
| Abstract | ||||
| Introduction: Breast cancer causes a profound upheaval of the body and mind. Dietary and lifestyle factors play a major role in the epidemiology of this pathology. Objective: The objective of this work was to characterize the epidemiological, clinical and histopathological profiles of the study population, and to analyze the hypothesis of a relationship between relatively high consumption of foods rich in fatty acids and breast cancer. Subjects and methods: We opted for a case-control study. It included 324 subjects. Data were collected from a basic questionnaire and a dietary survey. These data were completed following a review of the patients' medical records. Results: The average age of our patients was (49,66 ±10,72). Clinical data revealed a predominance of the location of breast carcinomas in the left breast (54,23%) compared to the right breast (43,84%). SBR classification showed that GII is the most common histopronostic grading, it accounts for (67,70%) of cases. Determination of Hormonal Receptor and HER2 status objectified a predominance of RH+/HER2- status with a rate of (59,45%). Patients with triple-negative status were (3,79%). Nutritional data revealed a positive association between a diet rich in fatty acids such as red meat (P=0,003) and dairy products (foods that are rich in long-chain Polyunsaturated Fatty Acids) and breast cancer. Conclusion: Of multiple origins, breast cancer is related to a set of factors. However, it is important to put lifestyle at the center of research because, currently, recent studies focus attention mainly on the association between high fat intake and breast cancer. | ||||
| Keywords | ||||
| Breast Cancer; Epidemiological; Clinical; Nutritional; Fatty Acids | ||||
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