Antioxidants as a Potential Therapy for Reduction of Oxidative Stress in Autistic Children | ||||
| Egyptian Journal of Chemistry | ||||
| Article 34, Volume 65, Issue 7, July 2022, Page 343-351 PDF (269.82 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2021.104004.4812 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Nevin Sharaf1; Gehan Moubarz   2; Hala Awadalla3; Noha Hegazy4; Amal Elsaied5; Ahmed Abdel Gawad6; Sara Said7
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| 1Professor of Environmental Medicine- Environmental and Occupational Medicine Department-National Research Centre, Giza, Egypt. | ||||
| 2Assist. Prof. of biochemistry and environmental molecular biology. Environmental and Occupational Medicine Department-National Research Centre, Giza, Egypt. | ||||
| 3Professor of Community and Environmental Medicine-Medical Science Department- Faculty of Graduate Studies and Environmental Research - Ain shams university, Cairo, Egypt. | ||||
| 4Professor of Occupational Medicine- Environmental and Occupational Medicine Department- National Research Centre, Giza, Egypt. | ||||
| 5Researcher of Clinical Genetics at Department of Children with Special Needs- National Research Centre, Giza, Egypt. | ||||
| 6Lecturer of Environmental Medical Science - Faculty of Graduate Studies and Environmental Research - Ain Shams University, Cairo, Egypt. | ||||
| 7Environmental and Occupational Medicine, National Research Center, Egypt | ||||
| Abstract | ||||
| Background: Recently, several studies showed oxidative stress in autism spectrum disorder (ASD) patients. Another study found oxidative stress state and mal detoxification of aluminum in autistic children. Zinc, vitamin C and vitamin E may play a significant role in the detoxification and overcoming the oxidative stress among children with autistic disorder. Objectives: A clinical trial was designed to evaluate the role of vitamin E, vitamin C and zinc oral supplementation on the oxidant-antioxidant status and the aluminum level among autistic children. Methods: Hair aluminum level (Al), malondialdehyde (MDA), Nitric Oxide (NO) and Glutathione S-Transferase (GST) activity, were estimated in 30 autistic children before and after vitamin E, vitamin C and zinc supplementation for three months. Results: After supplementation, the results revealed that hair aluminum level, MDA and NO of the children were significantly decreased. While, GST activity was significantly increased. In addition, the study showed improvement in childhood autism rating scale (CARS) score after antioxidant supplementations. As before supplementation, 7.8% of children were scored mild, 51.4% were scored moderate, and 40.8% were scored severe. While, after supplementation there were not any sever cases observed between examined children. Conclusions: Antioxidant supplementation through vitamin E, vitamin C and zinc apparently improved antioxidant status against oxidative stress among ASD children. This improvement in antioxidant status help in decreasing of aluminum level in autistic children with decreasing oxidative stress biomarkers (MDA, NO) and increasing detoxification enzyme (GST), which in turn leads to an improvement in childhood autism rating scale (CARS) score of autistic children. Thus, antioxidant supplementation may help as a protective supplementation from susceptibility to autism development in children with high aluminum level. | ||||
| Keywords | ||||
| autistic children; antioxidant enzymes; aluminum level; oxidative stress; vitamin C; vitamin E; and zinc supplementation | ||||
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