Nuclear factor-kappa B signaling pathways and parasitic infections: An overview | ||||
| Parasitologists United Journal | ||||
| Article 1, Volume 14, Issue 3, December 2021, Page 218-228 PDF (503.57 K) | ||||
| Document Type: Review Article | ||||
| DOI: 10.21608/puj.2021.91389.1129 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Samar Alhusseiny; Samar El-Beshbishi* | ||||
| Department of Medical Parasitology, Faculty of Medicine, Mansoura University, Mansoura 35516- Egypt | ||||
| Abstract | ||||
| Host nuclear factor-kappa B (NF-κB) transcription factor plays a pivotal role in innate immunity and resistance to infection. It induces the expression of several genes that encode pro-inflammatory cytokines. It also participates in regulating the differentiation and survival of innate immune cells and lymphocytes. Infection of host cells with pathogens usually activates host NF-κB signaling pathways. The majority of parasites evolved diverse protective mechanisms against NF-κB activity to shield their continued existence. Herein, we present brief insights into NF-κB signaling pathways, activators and inhibitors, and the main subsequent events following protozoan and helminthic infections in vitro, as well as in vivo either in experimental models, or in humans. Understanding the underlying mechanisms of NF-κB activation and inhibition may be of great help as a therapeutic strategy against different parasitic infections. | ||||
| Keywords | ||||
| helminths; innate immunity , novel drugs ,nuclear factor-kappa B , pro-inflammatory cytokines , protozoa , toll-like receptors | ||||
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