ASSESSMENT OF SPEM 1 AND INHIBIN IN PATIENTS WITH DYSFUNCTIONAL AZOOSPERMIA AND THEIR RELATION TO SUCCESSFUL SPERM RETRIEVAL | ||||
| ALEXMED ePosters | ||||
| Article 1, Volume 3, Issue 4, December 2021, Page 106-107 | ||||
| Document Type: Preliminary preprint short reports of original research | ||||
| DOI: 10.21608/alexpo.2021.111579.1331 | ||||
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| Authors | ||||
Adel Hassan El Beheiry1; tarek Mahmoud Hussein1; Raghda Saad Zaghloul Ahmed2; walid Marei Ahmed  1
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| 1Department of Dermatology, Venereology and Andrology | ||||
| 2Department of Clinical and Chemical Pathology | ||||
| Abstract | ||||
| Introduction Infertility is becoming a major public health concern with major psychological and economic impacts. Globally, up to 15% of couples suffer from infertility, in which almost a quarter of the cases are due to the male factor. Azoospermia refers to the complete lack of spermatozoa in the ejaculate, affecting 1% of all males and up to 15% of the infertile male population. Azoospermia can be categorized into obstructive azoospermia (OA); that is due to blockage along the male reproductive tract and non-obstructive azoospermia (NOA): that is due to dysfunctional spermatogenesis affecting about 60% of azoospermic men. Both cases of NOA and OA can benefit from testicular sperm extraction (TESE). In cases of NOA, micro-TESE has improved the chances of sperm retrieval by identifying foci of spermatogenesis in the testis with a success rate of 40-60%. To improve this outcome, it is necessary to have a reliable predictor of sperm retrieval. Several clinical parameters such as semen analysis, testicular size, FSH levels, inhibin B, and histopathology are among predictive factors for successful sperm retrieval in men with dysfunctional azoospermia. However, no accurate predictors have been identified. Aim of the work The aim of this study was to assess the gene expression of SPEM1 in testicular tissue and the level of serum Inhibin B in patients with dysfunctional azoospermia and to evaluate their predictive power for sperm retrieval. | ||||
| Keywords | ||||
| SPEM 1; INHIBIN; AZOOSPERMIA | ||||
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