Chlorella Vulgaris Extract protects against Sodium Nitrite Toxicity in Male Rats
Eissa, M., Ahmed, M., Attia, M., Orabi, S., Mousa, A., Mohamed, M. (2020). Chlorella Vulgaris Extract protects against Sodium Nitrite Toxicity in Male Rats. EKB Journal Management System, 3(1), 32-34. doi: 10.21608/djvs.2020.45000.1025
Mai Eissa; Mohamed Ahmed; Mabrouk Attia; Sahar Hassan Orabi; Ahmed Mousa; Mostafa Mohamed. "Chlorella Vulgaris Extract protects against Sodium Nitrite Toxicity in Male Rats". EKB Journal Management System, 3, 1, 2020, 32-34. doi: 10.21608/djvs.2020.45000.1025
Eissa, M., Ahmed, M., Attia, M., Orabi, S., Mousa, A., Mohamed, M. (2020). 'Chlorella Vulgaris Extract protects against Sodium Nitrite Toxicity in Male Rats', EKB Journal Management System, 3(1), pp. 32-34. doi: 10.21608/djvs.2020.45000.1025
Eissa, M., Ahmed, M., Attia, M., Orabi, S., Mousa, A., Mohamed, M. Chlorella Vulgaris Extract protects against Sodium Nitrite Toxicity in Male Rats. EKB Journal Management System, 2020; 3(1): 32-34. doi: 10.21608/djvs.2020.45000.1025

Chlorella Vulgaris Extract protects against Sodium Nitrite Toxicity in Male Rats

Damanhour Journal of Veterinary Sciences
Article 6, Volume 3, Issue 1, January 2020, Page 32-34  XML PDF (292.43 K)
Document Type: Original Article
DOI: 10.21608/djvs.2020.45000.1025
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Authors
Mai Eissa email 1; Mohamed Ahmed1; Mabrouk Attia2; Sahar Hassan Orabiorcid 1; Ahmed Mousa1; Mostafa Mohamed3
1Department of Biochemistry and Chemistry of Nutrition, Faculty of Veterinary Medicine, University of Sadat city, Egypt.
2Department of Biochemistry and Chemistry of Nutrition, Faculty of Veterinary Medicine, Menoufia University, Sheben Elkom, Egypt.
3Department of Pathology, Faculty of veterinary medicine, Menoufia University, Sheben Elkom, Egypt
Abstract
The current study was carried out to investigate the protective potential of Chlorella Vulgaris (CV) extract against sodium nitrite toxicity. Forty-five male Wister albino rats were assigned into 5 groups (n=9). Group (A) rats received normal saline orally for 3 months, Group (B): rats administered CV extract (70 mg/kg.BW) orally for 3 months, Group (C): rats received sodium nitrite (80 mg/kg.BW) orally for 3 months, Group (D): rats simultaneously received CV along with sodium nitrite treatment, orally, daily for 3 months, and Group (E): rats pre-treated with CV extract for 4 weeks followed by simultaneous treatment with sodium nitrite and CV extract for additional 8 weeks. Treatment of rats with sodium nitrite significantly increased serum urea and creatinine levels, associated with interstitial edema with mononuclear cells infiltrations, the renal tubular epithelium showed cloudy swelling and sever coagulative necrosis with desquamation of tubular epithelium and renal cast, the glomeruli showed congested glomerular capillaries. Besides, it decreased total leucocytic count and platelets count with normal hemoglobin, red blood cell count, hematocrit levels, mean corpuscular volume, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration. Pre-treatment and co-treatment of sodium nitrite-treated rats with CV in groups (D & E) significantly prevented sodium nitrite-induced alterations of renal function and histological architecture. This study indicated that CV extract ameliorates the renal dysfunction induced by sodium nitrite toxicity.
Keywords
Chlorella vulgaris; Sodium nitrite; kidney; platelets; total leucocytic count
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