The ameliorative effects of cinnamum zeylanicum extract on renal functions and oxidative stress against fluoxetine drug in male rats
Hashem, N., Abu Heakal, N., El-Emam, H., El-Ashry, E., Elghareeb, M. (2022). The ameliorative effects of cinnamum zeylanicum extract on renal functions and oxidative stress against fluoxetine drug in male rats. EKB Journal Management System, 23(2), 31-39. doi: 10.21608/mvmj.2021.111996.1098
Nada Hashem; Nabil Abu Heakal; Huda El-Emam; Eman Saleh El-Ashry; Mona M. Elghareeb. "The ameliorative effects of cinnamum zeylanicum extract on renal functions and oxidative stress against fluoxetine drug in male rats". EKB Journal Management System, 23, 2, 2022, 31-39. doi: 10.21608/mvmj.2021.111996.1098
Hashem, N., Abu Heakal, N., El-Emam, H., El-Ashry, E., Elghareeb, M. (2022). 'The ameliorative effects of cinnamum zeylanicum extract on renal functions and oxidative stress against fluoxetine drug in male rats', EKB Journal Management System, 23(2), pp. 31-39. doi: 10.21608/mvmj.2021.111996.1098
Hashem, N., Abu Heakal, N., El-Emam, H., El-Ashry, E., Elghareeb, M. The ameliorative effects of cinnamum zeylanicum extract on renal functions and oxidative stress against fluoxetine drug in male rats. EKB Journal Management System, 2022; 23(2): 31-39. doi: 10.21608/mvmj.2021.111996.1098

The ameliorative effects of cinnamum zeylanicum extract on renal functions and oxidative stress against fluoxetine drug in male rats

Mansoura Veterinary Medical Journal
Article 35, Volume 23, Issue 2, June 2022, Page 31-39  XML PDF (734.62 K)
Document Type: Original Articles
DOI: 10.21608/mvmj.2021.111996.1098
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Authors
Nada Hashem email orcid 1; Nabil Abu Heakal1; Huda El-Emam2; Eman Saleh El-Ashryorcid 3; Mona M. Elghareeb1
1Department of Physiology, Faculty of Veterinary Medicine, Mansoura University, Mansoura
2Department of Husbandry and Development of Animal Wealth, Faculty of Veterinary Medicine, Mansoura University, Mansoura 35516, Egypt.
3Pharmacology Department, Faculty of Veterinary medicine, Mansoura University
Abstract
Objective: To determine the effects of cinnamon against fluoxetine on renal function, lipid profiles and oxidative stress. Design: Randomized controlled study
Animals: Thirty-twoalbino rats
Procedures: Rats were allocated into four groups, control, FLX, Cin and FLX+ Cin group for 60 days.  Blood samples were collected for measurement of kidney, liver function and lipid profiles. The left kidney was taken for determination of oxidative stress parameters, histopathological evaluation and detection of levels of caspase, renin and NRF2 genes. Procedures: FLX group administered fluoxetine 10 mg/kg Bwt. Cin group administered cinnamon 50 mg/kg body weight. FLX+ Cin group received fluoxetine at a concentration of 10 mg/kg body weight and after 30 minutes received cinnamon extract at dose of 50 mg/kg body weight.
Results: Administration of fluoxetine exhibited a higher level of urea, uric acid and creatinine. Administration of Cin alone or with FLX improved kidney functions and antioxidant parameters. Marked increase was detected in FLX group compared to the Cin and Cin+FLX groups. Administration of cinnamon with fluoxetine leads to improvement in the lipid profiles. Moreover, there was a significant upregulation in renin and caspase 3 genes in FLX and FLX + Cin treated groups. The renal NRF2 was downregulated in FLX group and increased in Cin group. Histopathological pictures of renal sections showing tubular dilation with renal epithelial cells degeneration, necrosis and fibrosis in FLX group.
Conclusion and clinical relevance: Cinnamon may be used to counteract the negative effect of fluoxetine drug on renal tissue.
Keywords
Cinnamon; Fluoxetine; Renal function; oxidative stress; Histopathology and Renal genes
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