Evaluation of Antibacterial Activity of Calcium Phosphates Based Bone Cements for Biomedical Applications | ||||
Egyptian Journal of Chemistry | ||||
Article 30, Volume 65, Issue 8, August 2022, Page 323-335 PDF (479.82 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/ejchem.2021.110005.5013 | ||||
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Authors | ||||
Ammar Z. Alshemary 1, 2; Betül Sarsık1; Nader A. Salman3; Sitem Merve Şahin4; Mehmet Murat Şahin5; Yasser Muhammed6 | ||||
1Biomedical Engineering Department, Faculty of Engineering, Karabuk University, Karabuk, 78050, Turkey | ||||
2Biomedical Engineering Department, Al-Mustaqbal University College, Hillah, Babil, 51001, Iraq | ||||
3Al-Manara College for Medical Sciences, Maysan, 62001, Iraq | ||||
4Department of Bioengineering, Hacettepe University, Ankara, 06530, Turkey | ||||
5Family Physician, Kurtuluş Family Health Center, Karabük,78200, Turkey | ||||
6Aeronautical Techniques Engineering, AL-Farahidi University, Baghdad, Iraq | ||||
Abstract | ||||
In orthopedics and traumatology surgeries, the repair of bone deformities is a concern. Pure and cobalt (Co) doped calcium phosphate (CaP) cements were successfully prepared in this study. The particles that had been manufactured were characterized utilizing X-ray powder diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), and Scanning electron microscope (SEM) techniques. The lattice properties, degree of crystallinity, and particle size of pure and modified CaP bone cement were reduced dramatically when added cobalt ions. The functional groups of CaP bone cements were detected via the FTIR technique. Antibacterial properties of pure and Co doped CaP bone cement were evaluated qualitatively against Escherichia coli (E. Coli), Methicillin-sensitive Staphylococcus aureus (MSSA). Methicillin-resistant Staphylococcus aureus (MRSA), Methicillin-resistant coagulase-negative staphylococci (MR-CoNS), and Pseudomonas aeruginosa (P. aeruginosa) bacteria for 24 h at 37 ºC. The results showed that the addition of cobalt ions inhibited the growth of E. coli and MSSA bacteria. Antibacterial bone cements are potential material for preventing infection-related bone healing failures. | ||||
Keywords | ||||
Bone cements; Calcium Phosphate; Cobalt; Antibacterial properties | ||||
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