Turmeric Extracts as a Protective Natural Compound Against Hepatotoxicity Induced by Lead Nitrate in Male Albino Rat Model | ||||
| Arab Universities Journal of Agricultural Sciences | ||||
| Article 1, Volume 29, Issue 3, December 2021, Page 813-822 PDF (243.21 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ajs.2021.75154.1374 | ||||
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| Authors | ||||
Abd el-Fattah Abed Abd el-Fattah1; Medhat Abozid2; Kamal Mahmoud   3
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| 1Ministry of Health and Population, Cairo, Egypt. | ||||
| 2Biochemistry department, Faculty of Agriculture, Menoufia University, Shebin El-Kom, Menoufia, Egypt. | ||||
| 3Biochemistry department, Faculty of Agriculture, Menoufia University, Shebin El-Kom, Menoufia, Egypt | ||||
| Abstract | ||||
| Excessive exposure to lead may damage the liver by increasing oxidative stress, leading to many serious diseases. Dietary antioxidants may protect the liver from damage. Therefore, the effect of ethanolic and aqueous turmeric extracts against lead-induced liver damage was evaluated by estimating liver function and antioxidant/oxidative stress biomarkers. Forty rats were divided into group (A) served as the control and group (B) was treated with 93 mg/kg b.wt. lead nitrate; while group (C) and group (D) were treated as group B in addition to 400 mg/kg b.wt. of turmeric aqueous and ethanolic extracts, respectively. Group B showed a significant increase in the activities of alanine transaminase by 10 folds, aspartate transaminase by 9 folds, alkaline phosphatase by 3 folds and the level of malondialdehyde by 10 folds, while showed a significant decrease in albumin by 60%, total protein by 54.5%, and superoxide dismutase by 80.5%, catalase by 75% and glutathione by 71.6% in comparison with those of the control group. On the other hand, turmeric treatments (groups C and D) led to a readjustment of levels for such biomarkers. Collectively, these results demonstrate the potential of turmeric extracts (particularly the ethanolic extract) to improve the fatal effect of lead in a rat model. | ||||
| Keywords | ||||
| Turmeric; Lead nitrate; Liver function; Antioxidant; Extracts | ||||
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