Burden of parasitic infection and its impact on growth of children with hepatitis C Virus
Hassanin, F., Abbas, A., Ahmed, E., Schaalan, M., Raba, M. (2021). Burden of parasitic infection and its impact on growth of children with hepatitis C Virus. EKB Journal Management System, 6.1(1), 17-23. doi: 10.21608/mjvh.2021.211708
Fetouh Hassanin; Azza Hasan Abbas; El Shahat Ahmed; Mona Schaalan; Mohamed Raba. "Burden of parasitic infection and its impact on growth of children with hepatitis C Virus". EKB Journal Management System, 6.1, 1, 2021, 17-23. doi: 10.21608/mjvh.2021.211708
Hassanin, F., Abbas, A., Ahmed, E., Schaalan, M., Raba, M. (2021). 'Burden of parasitic infection and its impact on growth of children with hepatitis C Virus', EKB Journal Management System, 6.1(1), pp. 17-23. doi: 10.21608/mjvh.2021.211708
Hassanin, F., Abbas, A., Ahmed, E., Schaalan, M., Raba, M. Burden of parasitic infection and its impact on growth of children with hepatitis C Virus. EKB Journal Management System, 2021; 6.1(1): 17-23. doi: 10.21608/mjvh.2021.211708

Burden of parasitic infection and its impact on growth of children with hepatitis C Virus

Medical Journal of Viral Hepatitis
Article 4, Volume 6.1, Issue 1, December 2021, Page 17-23  XML PDF (334.97 K)
Document Type: Original article
DOI: 10.21608/mjvh.2021.211708
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Authors
Fetouh Hassanin email orcid 1; Azza Hasan Abbas2; El Shahat Ahmed3; Mona Schaalan4; Mohamed Raba5
1Pediatrics, Misr International University, Cairo, Egypt
2Medical Parasitology, Immunology and Microbiology Department,National Hepatology and Tropical Medicine Research Institute (NHTMI), Cairo, Egypt
3Medical Parasitology, Immunology and Microbiology Department,National Hepatology and Tropical Medicine Research Institute (NHTMI), Cairo, Egypt.
4Clinical Pharmacy department (Biochemistry), Misr International University, Cairo, Egypt
5Department of Pediatric Gastroenterology,National Hepatology and Tropical Medicine Research Institute (NHTMI), Cairo, Egypt
Abstract
 
Background: Egypt showed high infection rates of intestinal parasites especially in the rural areas. Children suffering of HCV are considered immunocompromised which makes them vulnerable to a wide spectrum of parasitic infections. The aim of the study is to assess the impact of different protozoa and helminthes infection on growth of children with hepatitis C virus infection (HCV).
Materials and methods:This study was conducted at National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt and included 115 children who proved to have HCV infection by PCR.  In addition, 144 non-HCV infected children were enrolled as control group. Both groups were clinically assessed and investigated for the presences of parasites infestation and their effects on growth in HCV infected children.
Results: Percentage of helminthes’ infection in the HCV infected children’s was significantly higher than that of the control group (P = 0.001). Parasitic infections have negative impacts on growth in HCV infected children. In HCV children co-infected with parasites, the weight and height percentiles were significantly lower compared to those HCV infected group without parasitic infection (P = 0.001, 0.002; respectively). In HCV-infected groups, there was a significant positive correlation of albumin with weight percentile (r = 0.318 and p= 0.000) and height percentile (r = 0.316 and p= 0.000).
Conclusions: Children with hepatitis C virus infection are vulnerable to parasitic infections. Parasitic co-infection of HCV affected children has a negative impact on their growth and general health. 
Keywords
HCV; Pediatrics; helminthes; protozoa
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