Role of interferon gamma gene polymorphism in spontaneous viral clearance versus chronicity in hepatitis C infected Egyptian patients | ||||
| Medical Journal of Viral Hepatitis | ||||
| Article 5, Volume 6.1, Issue 1, December 2021, Page 24-31 PDF (283.98 K) | ||||
| Document Type: Original article | ||||
| DOI: 10.21608/mjvh.2021.211709 | ||||
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| Authors | ||||
Maha R Habeeb  1; Rokia Anwar Saad2; Dina Elhammady3; Maysaa ElSayed Zaki4; Neven Farouk Abbas2
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| 1Internal Medicine Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt. | ||||
| 2Department of Internal Medicine, Faculty of Medicine, Mansoura University, Mansoura, Egypt. | ||||
| 3Department of Tropical Medicine, Faculty of Medicine, Mansoura University, Mansoura, Egypt. | ||||
| 4Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt | ||||
| Abstract | ||||
| Background: Polymorphisms in the cytokine gene involving IFN gamma (IFN-γ) have been implicated in many infections including HCV. The aim of this study is to evaluate the association between IFN-γ polymorphism in three regions, (+2109A/G, +874A/T, -183G/T) and either chronicity or spontaneous viral clearance (SCV) in HCV infected patients. Materials and Methods: The study included 200 HCV-infected patients divided into Group I of 100 patients with spontaneous virus clearance (SVC) and Group II of 100 patients with persistent chronic hepatitis C infection (PI) who did not receive any therapy. These patients were subjected to history taking, full clinical examination and laboratory investigations included analysis of IFN-γ gene polymorphisms. Results: At locus +2109 of the IFN-γ gene, patients with A/A genotype had a significantly higher rate of spontaneous hepatitis C clearance while the G/G genotype was more prone to persistent infection. No statistically significant difference was found between both groups regarding loci +874 and -183 of the IFN-γ gene, but column proportion comparison using Bonferroni method at locus +874 revealed a higher proportion for T/A genotype in SVC group. Both haplotypes AAT and TGT were more susceptible to chronic HCV infection, as were heterozygote T/A at locus +874 and G/G genotype at locus +2109s. A/G and A/A genotypes at locus +2109, TLC at cut off value ≤7.15, and AST at cut off value ≤27.5 were considered independent predictors for development of SVC. Conclusions: Polymorphisms in the IFN-γ gene may play role in sequelae following HCV infection, possibly determining whether the virus will be cleared spontaneously or not. | ||||
| Keywords | ||||
| IFN- γ gene polymorphism; spontaneous viral clearance; HCV | ||||
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