Correlation of Serum Levels of Interleukin‑1β and CCL 24 with Severity of Persistent Allergic Rhinitis in Children
Abdallah, A., El Maghraby, H., El Gandy, M., Shabana, M., Mohammed, H. (2022). Correlation of Serum Levels of Interleukin‑1β and CCL 24 with Severity of Persistent Allergic Rhinitis in Children. EKB Journal Management System, 31(1), 1-6. doi: 10.21608/ejmm.2022.211920
Alshimaa L. Abdallah; Hanaa M. El Maghraby; Mohamed S. El Gandy; Marwa A. Shabana; Heba A. Mohammed. "Correlation of Serum Levels of Interleukin‑1β and CCL 24 with Severity of Persistent Allergic Rhinitis in Children". EKB Journal Management System, 31, 1, 2022, 1-6. doi: 10.21608/ejmm.2022.211920
Abdallah, A., El Maghraby, H., El Gandy, M., Shabana, M., Mohammed, H. (2022). 'Correlation of Serum Levels of Interleukin‑1β and CCL 24 with Severity of Persistent Allergic Rhinitis in Children', EKB Journal Management System, 31(1), pp. 1-6. doi: 10.21608/ejmm.2022.211920
Abdallah, A., El Maghraby, H., El Gandy, M., Shabana, M., Mohammed, H. Correlation of Serum Levels of Interleukin‑1β and CCL 24 with Severity of Persistent Allergic Rhinitis in Children. EKB Journal Management System, 2022; 31(1): 1-6. doi: 10.21608/ejmm.2022.211920

Correlation of Serum Levels of Interleukin‑1β and CCL 24 with Severity of Persistent Allergic Rhinitis in Children

Egyptian Journal of Medical Microbiology
Article 1, Volume 31, Issue 1, January 2022, Page 1-6  XML PDF (333.26 K)
Document Type: New and original researches in the field of Microbiology.
DOI: 10.21608/ejmm.2022.211920
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Authors
Alshimaa L. Abdallah email 1; Hanaa M. El Maghraby2; Mohamed S. El Gandy2; Marwa A. Shabana3; Heba A. Mohammed3
1Lecturer of Medical Microbiology and Immunology, Faculty of Medicine, Zagazig University, Egypt.
2Otolaryngology Department, Faculty of Medicine, Zagazig University, Egypt
3Clinical Pathology Department, Faculty of Medicine - Zagazig University, Egypt
Abstract
Background: Allergic rhinitis (AR) is a distressing clinical presentation especially in pediatric age which affects quality of life and may predispose to bronchial asthma. Various inflammatory biomarkers might be involved in allergic rhinitis pathogenesis and correlated with its severity such as IL1 β and CCL 24. Objectives: This study aims to detect serum level of IL 1 β and CCL24 in studied pediatric patients and correlate their levels with the severity of allergic rhinitis and with comorbid asthma in children. Methodology: Peripheral bloodeosinophil count was detected andserum level of IgE, IL1 β and CCL24 were assayed in pediatric patients with allergic rhinitis using ELISA. In addition, correlation of their levels with the severity of AR. Results: Eosinophil count and serum levels of IL1 β and CCL24 were significantly elevated in (AR) patients compared with the controls (P=0.00001*), (P=0.026*) and (P=0.017*) respectively. Parental smoking and Associated Asthma of high statistical significance when correlated with severity of allergic rhinitis (P=0.005) and (P<0.001) respectively. Family history of allergy& allergy in other sibling were also significantly correlated with severity of AR (P=0.093) and (P=0.02) respectively. Conclusion: This study clarifies the evidence that IL-1β is an important inflammatory biomarker for pathogenesis and severity of allergic rhinitis and it might predispose to other allergic diseases subsequently it may be investigated as a therapeutic target especially in severe cases.
Keywords
IL-1β; CCL24; Allergic Rhinitis and Children
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