Correlation between Highly Sensitive C Reactive Protein and Development of Microvascular Complications of Type 2 Diabetes Mellitus
Hassaan, A., Abd El-Ghany, M., Eldars, W., Othman, T. (2022). Correlation between Highly Sensitive C Reactive Protein and Development of Microvascular Complications of Type 2 Diabetes Mellitus. EKB Journal Management System, 31(1), 69-73. doi: 10.21608/ejmm.2022.211968
Amal Hassaan; Mohamed I. Abd El-Ghany; Waleed Eldars; Talat A. Othman. "Correlation between Highly Sensitive C Reactive Protein and Development of Microvascular Complications of Type 2 Diabetes Mellitus". EKB Journal Management System, 31, 1, 2022, 69-73. doi: 10.21608/ejmm.2022.211968
Hassaan, A., Abd El-Ghany, M., Eldars, W., Othman, T. (2022). 'Correlation between Highly Sensitive C Reactive Protein and Development of Microvascular Complications of Type 2 Diabetes Mellitus', EKB Journal Management System, 31(1), pp. 69-73. doi: 10.21608/ejmm.2022.211968
Hassaan, A., Abd El-Ghany, M., Eldars, W., Othman, T. Correlation between Highly Sensitive C Reactive Protein and Development of Microvascular Complications of Type 2 Diabetes Mellitus. EKB Journal Management System, 2022; 31(1): 69-73. doi: 10.21608/ejmm.2022.211968

Correlation between Highly Sensitive C Reactive Protein and Development of Microvascular Complications of Type 2 Diabetes Mellitus

Egyptian Journal of Medical Microbiology
Article 10, Volume 31, Issue 1, January 2022, Page 69-73  XML PDF (314.51 K)
Document Type: New and original researches in the field of Microbiology.
DOI: 10.21608/ejmm.2022.211968
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Authors
Amal Hassaan1; Mohamed I. Abd El-Ghany2; Waleed Eldars email orcid 3; Talat A. Othman1
1Medical Microbiology and Immunology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt
2Department of Internal medicine, Faculty of Medicine, Mansoura University, Mansoura, Egypt
3Department of Medical Microbiology and Immunology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Abstract
Background: Microvascular problems associated with type 2 diabetes mellitus (T2DM) are a leading source of morbidity and mortality in T2DM patients, thus the search for new biomarkers to identify and treat those at high risk is intensifying. Objective: This controlled cross-sectional study aimed to investigate whether there is a correlation between serum levels of highly sensitive C reactive protein (hsCRP) and development of microvascular complications in T2DM.Methodology:  Hundred and thirty-five subjects aged from 35 to 70 years were subdivided into 3 groups. Detailed clinical history was taken. Serum levels of hsCRP were estimated using Immune Turbidimetry. Results: Serum hsCRP levels were higher in group A than other studied groups. However, there was no statistically significant difference between group A and B(P=0.35). Serum hsCRP levels were significantly higher in patients with diabetic nephropathy than patients without nephropathy (P=0.016). The difference between serum hsCRP levels in patients with and without retinopathy and neuropathy was not significant (P=0.39 and P=0.53 respectively). Conclusion: Serum hsCRP can be used as a novel marker for diagnosis of microvascular complications in T2DM patients.
Abbreviations: (T2DM: Type 2 Diabetes Mellitus, hsCRP: highly sensitive C Reactive Protein, eGFR: Estimated Glomerular filteration Rate, BUN: Blood Urea Nitrogen, HbA1c: Glycosylated Hemoglobin). 
Keywords
T2DM; microvascular complications; hsCRP
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