Prevalence of Acquired Colistin Resistance among Gram Negative Bacilli Isolated from Patients Admitted at Cairo University Hospitals
Sorour, A., Ibrahim, K., Hegab, A. (2022). Prevalence of Acquired Colistin Resistance among Gram Negative Bacilli Isolated from Patients Admitted at Cairo University Hospitals. EKB Journal Management System, 31(1), 97-104. doi: 10.21608/ejmm.2022.211995
Ashraf E. Sorour; Karim Abdo Abdo Ibrahim; Asmaa Hegab. "Prevalence of Acquired Colistin Resistance among Gram Negative Bacilli Isolated from Patients Admitted at Cairo University Hospitals". EKB Journal Management System, 31, 1, 2022, 97-104. doi: 10.21608/ejmm.2022.211995
Sorour, A., Ibrahim, K., Hegab, A. (2022). 'Prevalence of Acquired Colistin Resistance among Gram Negative Bacilli Isolated from Patients Admitted at Cairo University Hospitals', EKB Journal Management System, 31(1), pp. 97-104. doi: 10.21608/ejmm.2022.211995
Sorour, A., Ibrahim, K., Hegab, A. Prevalence of Acquired Colistin Resistance among Gram Negative Bacilli Isolated from Patients Admitted at Cairo University Hospitals. EKB Journal Management System, 2022; 31(1): 97-104. doi: 10.21608/ejmm.2022.211995

Prevalence of Acquired Colistin Resistance among Gram Negative Bacilli Isolated from Patients Admitted at Cairo University Hospitals

Egyptian Journal of Medical Microbiology
Article 14, Volume 31, Issue 1, January 2022, Page 97-104  XML PDF (497.42 K)
Document Type: New and original researches in the field of Microbiology.
DOI: 10.21608/ejmm.2022.211995
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Authors
Ashraf E. Sorourorcid 1; Karim Abdo Abdo Ibrahim1; Asmaa Hegab email orcid 2
1Department of Medical Microbiology and Immunology, Faculty of Medicine, Cairo University, Egypt
2Deartment of Medical Microbiology and Immunology, Faculty of Medicine, Cairo University, Cairo11562, Egypt
Abstract
Background: Polymyxins were mostly ignored few decades ago because of their toxicity.  Now are considered as a last-line therapy to treat infections caused by multidrug resistant Gram-negative bacilli. Colistin resistance mediated by chromosomal mutations and more recently by plasmid‐borne mcr genes, is increasingly being reported in different countries. Objective: The aim of the present study is to determine the prevalence of acquired colistin resistance among gram negative bacilli isolates as well as to compare colistin resistance among different Gram-negative bacilli spp. It also aimed to study the antibiotic susceptibility of different Gram-negative bacilli isolates. Methodology: A total of 180 different clinical specimens were collected from the patients admitted at different Departments of Cairo University Hospitals until 115-Gram negative bacilli isolates were isolated. Results: The prevalence of acquired colistin resistance among gram negative bacilli isolates was found to be 10.4% (12/115). The prevalence of colistin resistance among different Gram-negative bacilli isolates was as follows: 12.5% among E. coli (3/24), 9.5% among Klebsiella spp. (4/42), 13.8% among Pseudomonas spp. (4/29) and 5.0% among Acinetobacter spp. (1/20). The overall colistin resistance rate among Enterobacteriaceae was 10.6% (7/66) while the overall colistin resistance rate among gram negative bacilli was 10.4% (12/115). Conclusions: Two-thirds (66.7%) of colistin resistant Gram-negative bacilli isolates were isolated from ICUs compared to other departments. All colistin resistant Gram-negative bacilli isolates were isolated from hospital acquired infections.
Keywords
Polymyxins; colistin; gram negative bacilli; colistin resistance; broth microdilution
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