Synthesis, Antimicrobial, Antioxidant and Docking Study of Some Novel 3,5-Disubstituted-4,5-dihydro-1H-pyrazoles Incorporating Imine Moiety
Abid, S., Abdula, A., Al Marjani, M., Abdulhameed, Q. (2019). Synthesis, Antimicrobial, Antioxidant and Docking Study of Some Novel 3,5-Disubstituted-4,5-dihydro-1H-pyrazoles Incorporating Imine Moiety. EKB Journal Management System, 62(4), 739-749. doi: 10.21608/ejchem.2018.5804.1498
Saja Abid; Ahmed Mutanabbi Abdula; Mohammed Al Marjani; Qais Abdulhameed. "Synthesis, Antimicrobial, Antioxidant and Docking Study of Some Novel 3,5-Disubstituted-4,5-dihydro-1H-pyrazoles Incorporating Imine Moiety". EKB Journal Management System, 62, 4, 2019, 739-749. doi: 10.21608/ejchem.2018.5804.1498
Abid, S., Abdula, A., Al Marjani, M., Abdulhameed, Q. (2019). 'Synthesis, Antimicrobial, Antioxidant and Docking Study of Some Novel 3,5-Disubstituted-4,5-dihydro-1H-pyrazoles Incorporating Imine Moiety', EKB Journal Management System, 62(4), pp. 739-749. doi: 10.21608/ejchem.2018.5804.1498
Abid, S., Abdula, A., Al Marjani, M., Abdulhameed, Q. Synthesis, Antimicrobial, Antioxidant and Docking Study of Some Novel 3,5-Disubstituted-4,5-dihydro-1H-pyrazoles Incorporating Imine Moiety. EKB Journal Management System, 2019; 62(4): 739-749. doi: 10.21608/ejchem.2018.5804.1498

Synthesis, Antimicrobial, Antioxidant and Docking Study of Some Novel 3,5-Disubstituted-4,5-dihydro-1H-pyrazoles Incorporating Imine Moiety

Egyptian Journal of Chemistry
Article 13, Volume 62, Issue 4, April 2019, Page 739-749  XML PDF (1.89 MB)
Document Type: Original Article
DOI: 10.21608/ejchem.2018.5804.1498
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Authors
Saja Abid1; Ahmed Mutanabbi Abdula email orcid 1; Mohammed Al Marjani2; Qais Abdulhameed3
1Department of Chemistry, College of Science, Mustansiriyah University, Baghdad, Iraq
2Department of Biology, College of Science, Mustansiriyah University, Baghdad, Iraq
3Department of dentistry, Al-Yarmouk University College, Baghdad, Iraq
Abstract
A novel series of 3,5-Disubstituted-4,5-Dihydro-1H-pyrazoles (3-9) containing imine moiety were synthesized and characterized using spectral analysis. The synthesized derivatives were In vitro screened against several bacterial species, Staphylococcus aureus, Pseudomonas aeruginosa and Acinetobacter baumannii as well as Candida albicans and revealed moderate to potent activity. The antioxidant study was confirmed for the synthesized derivatives against 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical qualitatively using TLC technique, and quantitatively by spectrophotometric method. The half maximal inhibitory concentration (IC50) was calculated for the active compounds (1-5, 8). Docking study for the potent compounds (2 and 4) against glucosamine-6-phosphate synthase, the target enzyme for the antimicrobial agents, was explored to explain the interactions of the discovered hits within the amino acid residues of the enzyme active side. The docking parameters enhanced the activity of new compounds as promising antimicrobial agents.
Keywords
2-Pyrazoline Schiff base; Antimicrobial; antioxidant; Docking study
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